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Systematic opinions with time-to-event (TTE) analyses present basic insights in lots of areas of analysis. TTE knowledge point out not solely whether or not occasions (e.g. deaths) have occurred, but in addition how a lot time has elapsed between the beginning of a examine and the prevalence of an occasion. Effectively-known examples are survival curves, which present how the proportion of sufferers who survive modifications over time, or hazard ratios, which evaluate the mortality charges of two teams.
TTE analyses are methodologically difficult. Earlier analysis has already highlighted shortcomings within the presentation of TTE outcomes and analyses in scientific trial publications. On this paper, the authors for the primary time evaluated the traits and strategies of meta-analytic TTE analyses in systematic opinions.
To this finish, they used a scientific search to determine 50 Cochrane opinions with meta-analyses based mostly on hazard ratios and 50 different systematic opinions from an important scientific journals.
The analysis is printed within the journal BMC Medical Analysis Methodology and the Journal of Scientific Epidemiology.
Their analysis reveals that present systematic opinions containing meta-analyses based mostly on hazard ratios present very completely different and sometimes insufficient data on TTE traits and strategies. In a earlier publication, the authors had already discovered this for publications on particular person scientific trials. The issue due to this fact persists in systematic opinions.
The authors conclude that evaluate authors ought to constantly use the accessible methodological pointers for TTE meta-analyses. Furthermore, further reporting requirements for TTE analyses in systematic opinions can enhance the standard of the opinions and thus the usability of their outcomes.
Extra data:
Marius Goldkuhle et al, Exploring the traits, strategies and reporting of systematic opinions with meta-analyses of time-to-event outcomes: a meta-epidemiological examine, BMC Medical Analysis Methodology (2024). DOI: 10.1186/s12874-024-02401-4
Marius Goldkuhle et al, Meta-epidemiological evaluate recognized variable reporting and dealing with of time-to-event analyses in publications of trials included in meta-analyses of systematic opinions, Journal of Scientific Epidemiology (2023). DOI: 10.1016/j.jclinepi.2023.05.023
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Analysis group finds shortcomings in documentation of time-to-event analyses in systematic opinions (2024, December 2)
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