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For kids and youths dwelling with migraine, there could also be a brand new preventive remedy, in keeping with a preliminary research launched at this time, February 26, 2025, that can be offered on the American Academy of Neurology’s 77th Annual Assembly going down April 5–9, 2025, in San Diego and on-line. Researchers discovered the drug zonisamide, which has been used to deal with seizures, could cut back migraine days on this age group. This research doesn’t show that zonisamide reduces migraine days; it solely exhibits an affiliation.
“Migraine disease is debilitating and can lead to kids having to miss school and other activities,” mentioned creator Anisa Kelley, MD, of Northwestern College Feinberg Faculty of Medication in Chicago. “Currently, there is only one FDA-approved migraine preventative medication for this age group. Our results are encouraging, showing zonisamide may be another option for reducing migraine attacks.”
For the research, researchers reviewed well being data at one establishment. They recognized 256 youngsters and youths who had been recognized with migraine and prescribed preventative zonisamide. Of those contributors, 28% had difficult-to-treat migraine, which was outlined as having migraine illness unsuccessfully handled with two or extra earlier drugs. Researchers documented the variety of headache days per thirty days for every participant each earlier than and after beginning zonisamide.
They then divided contributors into three subgroups based mostly on how lengthy they took the treatment earlier than a follow-up go to with a doctor. The primary group adopted up within the first month, the second group inside two to 6 months, and the third group after six months.
For all contributors, the median variety of headache days per thirty days was lowered from 18 to 6 on the first follow-up go to. When evaluating between the teams, the subgroup that adopted up inside two to 6 months had the biggest discount, with a median lower of six headache days per thirty days. Kelley famous that the info recommended the drug was best after at the very least two months of use.
The info additionally recommended that the drug was efficient for each these with difficult-to-treat migraine illness and people with out.
“It’s very exciting that we may have an effective way to treat difficult migraine disease in children and teens. However, it’s important to note that our study did have limitations,” mentioned Kelley. “For instance, our study did not compare people taking the medication to people who did not take the medication. Future studies are needed with control groups to confirm our results.”
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Zonisamide could stop some migraine assaults in youngsters and youths (2025, February 26)
retrieved 26 February 2025
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