We collect cookies to analyze our website traffic and performance; we never collect any personal data. Cookie Policy
Accept
NEW YORK DAWN™NEW YORK DAWN™NEW YORK DAWN™
Notification Show More
Font ResizerAa
  • Home
  • Trending
  • New York
  • World
  • Politics
  • Business
    • Business
    • Economy
    • Real Estate
  • Crypto & NFTs
  • Tech
  • Lifestyle
    • Lifestyle
    • Food
    • Travel
    • Fashion
    • Art
  • Health
  • Sports
  • Entertainment
Reading: Genome-edited stem cells reveal new hope for weight problems remedy with out muscle loss
Share
Font ResizerAa
NEW YORK DAWN™NEW YORK DAWN™
Search
  • Home
  • Trending
  • New York
  • World
  • Politics
  • Business
    • Business
    • Economy
    • Real Estate
  • Crypto & NFTs
  • Tech
  • Lifestyle
    • Lifestyle
    • Food
    • Travel
    • Fashion
    • Art
  • Health
  • Sports
  • Entertainment
Follow US
NEW YORK DAWN™ > Blog > Health > Genome-edited stem cells reveal new hope for weight problems remedy with out muscle loss
Genome-edited stem cells reveal new hope for weight problems remedy with out muscle loss
Health

Genome-edited stem cells reveal new hope for weight problems remedy with out muscle loss

Last updated: March 7, 2025 10:49 pm
Editorial Board Published March 7, 2025
Share
SHARE

A schematic diagram illustrating our workflow using CRISPR/Cas9-based prime modifying of hESCs to review the results of a selected FTO SNP on mobile differentiation. Credit score: Nature Communications (2025). DOI: 10.1038/s41467-024-53820-2

In a examine printed in Nature Communications, researchers on the Beijing Institute of Stem Cells and Regeneration (BISCRM) and the Institute of Zoology (IOZ) have cracked the code of the infamous FTO gene, reconciling its twin function in weight problems and muscle development. The revelation may enhance weight problems and diabetes therapies, probably providing an alternative choice to widespread GLP-1 receptor agonists that will trigger undesirable muscle losing.

“We’ve solved a long-standing puzzle in obesity genetics,” declares Dr. Ng Shyh-Chang, the examine’s lead creator. “We now understand how a single genetic variant can be Jekyll and Hyde—accelerating muscle growth in youth but also accelerating aging-related decay later in life.”

The examine zeroes in on the FTO gene variant rs9939609-A, a standard genetic quirk linked to elevated weight problems danger in ~45% of Europeans, ~24% of Africans, ~30% of East Asians, and ~35% of South Asians. This A variant, the researchers found, units off a mobile chain response involving H19 and IGF2 genes to speed up growth, initially boosting muscle development however finally exhausting the stem cells, resulting in untimely ageing.

In a startling twist, the staff discovered that stem cells carrying this variant quickly became skeletal muscle tissue, but in addition quickly developed insulin resistance when uncovered to high-fat situations. This means that skeletal muscle could possibly be the primary domino to fall within the FTO variant’s affect on accelerated growth and ageing.

“This study rewrites our understanding of how type 2 diabetes develops,” Dr. Ng Shyh-Chang explains.

“We’ve known that reduced glucose clearance and high insulin levels appear decades before diagnosis of type 2 diabetes. Now using CRISPR genome editing, we have a new human tissue avatar that explains how it all starts in the muscles for humans with rs9939609-A.”

This paradigm-shifting analysis not solely deepens our grasp of weight problems genetics but in addition gives a platform to display screen for higher CRISPR-based medication or small molecules for the tens of millions grappling with chubby points and muscle losing from present therapies.

Because the race for higher weight problems therapies intensifies, this breakthrough could possibly be the important thing to unlocking new therapeutic methods that finely management FTO to trim fats whereas boosting muscle development.

Extra data:
Lu Guang et al, An obesogenic FTO allele causes accelerated growth, development and insulin resistance in human skeletal muscle cells, Nature Communications (2025). DOI: 10.1038/s41467-024-53820-2

Offered by
Beijing Institute of Stem Cells and Regeneration

Quotation:
Genome-edited stem cells reveal new hope for weight problems remedy with out muscle loss (2025, March 7)
retrieved 7 March 2025
from https://medicalxpress.com/information/2025-03-genome-stem-cells-reveal-obesity.html

This doc is topic to copyright. Other than any honest dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.

You Might Also Like

Chromatin group linked to p53 tumor suppression mechanism

Southern China hit by outbreak of mosquito-borne an infection chikungunya

Kinshasa slum battles lethal cholera outbreak

Ritz replace: FDA points threat warning as a consequence of undeclared peanuts in some cracker sandwiches

Suboptimal dialysis initiation frequent in sufferers with superior CKD

TAGGED:cellsGenomeeditedhopelossmuscleObesityrevealSTEMtreatment
Share This Article
Facebook Twitter Email Print

Follow US

Find US on Social Medias
FacebookLike
TwitterFollow
YoutubeSubscribe
TelegramFollow
Popular News
What to Do With Your Life in April—30 Concepts to Encourage the Final Refresh
Lifestyle

What to Do With Your Life in April—30 Concepts to Encourage the Final Refresh

Editorial Board April 1, 2025
How Peng Shuai Went From ‘Chinese Princess’ to Silenced #MeToo Accuser
At House With the Final Inheritor of a Pissarro Portray Looted by Nazis
Home Republicans vote to rename Kennedy Heart opera home after Melania Trump
New imaging method reveals detailed map of mind’s blood movement in 3D

You Might Also Like

Keurig Okay-Cups recalled as a consequence of potential ink contamination
Health

Keurig Okay-Cups recalled as a consequence of potential ink contamination

July 25, 2025
Laminin-411 peptide reveals promise for central nervous system myelin restore
Health

Laminin-411 peptide reveals promise for central nervous system myelin restore

July 25, 2025
Elite soccer gamers grasp the artwork of trapping with out breaking their stride: Examine
Health

Elite soccer gamers grasp the artwork of trapping with out breaking their stride: Examine

July 25, 2025
Gene remedy trial gives breakthrough for uncommon genetic dysfunction
Health

Gene remedy trial gives breakthrough for uncommon genetic dysfunction

July 25, 2025

Categories

  • Health
  • Sports
  • Politics
  • Entertainment
  • Technology
  • World
  • Art

About US

New York Dawn is a proud and integral publication of the Enspirers News Group, embodying the values of journalistic integrity and excellence.
Company
  • About Us
  • Newsroom Policies & Standards
  • Diversity & Inclusion
  • Careers
  • Media & Community Relations
  • Accessibility Statement
Contact Us
  • Contact Us
  • Contact Customer Care
  • Advertise
  • Licensing & Syndication
  • Request a Correction
  • Contact the Newsroom
  • Send a News Tip
  • Report a Vulnerability
Term of Use
  • Digital Products Terms of Sale
  • Terms of Service
  • Privacy Policy
  • Cookie Settings
  • Submissions & Discussion Policy
  • RSS Terms of Service
  • Ad Choices
© 2024 New York Dawn. All Rights Reserved.
Welcome Back!

Sign in to your account

Lost your password?