Graphical summary. Credit score: Mind Communications (2025). DOI: 10.1093/braincomms/fcaf067
The elements of the mind which can be wanted to recollect phrases, and the way these are affected by a typical type of epilepsy, have been recognized by a crew of neurologists and neurosurgeons at UCL.
The brand new examine, printed in Mind Communications, discovered that shrinkage within the entrance and aspect of the mind (prefrontal, temporal and cingulate cortices, and the hippocampus) was linked to problem remembering phrases.
The brand new discovery highlights how the community that’s concerned in creating and storing phrase recollections is dispersed all through the mind.
That is significantly essential for serving to to know circumstances akin to epilepsy, wherein sufferers might have problem with remembering phrases. The researchers hope that their findings will assist information neurosurgical therapy for sufferers with epilepsy by serving to surgeons to keep away from elements of the mind necessary for language and reminiscence, which will in any other case be affected, when doing operations.
Corresponding creator, Professor John Duncan (UCL Queen Sq. Institute of Neurology) stated, “Having the ability to keep in mind and recall phrases is necessary for day-to-day reminiscence to work properly.
“Detailed MRI mind scans are used to seek out out the causes of epilepsy and might present if any elements of the mind are shrunken. By measuring the elements of the mind which can be shrunken and the way properly an individual can keep in mind phrases, we will work out which elements of the mind are used for making and storing recollections.
“In addition, if medication has not stopped seizures occurring, this helps us to guide neurosurgical treatment for a person’s epilepsy, to avoid damaging the parts of the brain that are needed for memory to work well.”
Within the first examine of its form, the researchers examined 84 folks with temporal lobe epilepsy (epilepsy arising from the temporal lobe on the sides of the pinnacle) and hippocampal sclerosis (a situation wherein a part of the mind is scarred, and reminiscence is affected) and 43 wholesome folks.
The sufferers had been divided into these with left-sided and right-sided hippocampal sclerosis.
Excessive-resolution MRI scans had been used to measure the dimensions and form of various elements of the mind, together with the cerebral cortex (the outer layer of the mind answerable for pondering, reminiscence, consideration, notion, consciousness, and language) and particular areas throughout the hippocampus (the a part of the mind that helps with studying, reminiscence, and spatial navigation).
All members underwent standardized assessments to evaluate their verbal reminiscence. These assessments had been a part of the Grownup Reminiscence and Data Processing Battery, which measures how properly folks can keep in mind and recall phrases.
The researchers then in contrast the reminiscence check scores to the sizes of various mind areas, to see if smaller mind elements had been linked to worse reminiscence.
They discovered that smaller sizes in sure mind areas, just like the prefrontal, temporal and cingulate cortices, and elements of the hippocampus, had been linked to worse reminiscence for phrases in folks with epilepsy arising of their temporal lobes.
These findings are additionally necessary for understanding how the mind organizes and remembers phrases.
Lead creator, Dr. Giorgio Fiore (Nationwide Hospital for Neurology and Neurosurgery, UCLH) stated, “This research is important as it helps us to understand how memory may fail and may help guide the designing of neurosurgical operations for epilepsy that will not make memory worse.”
Extra info:
Giorgio Fiore et al, Cortico-hippocampal networks underpin verbal reminiscence encoding in temporal lobe epilepsy, Mind Communications (2025). DOI: 10.1093/braincomms/fcaf067
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Elements of the mind which can be wanted to recollect phrases recognized (2025, March 19)
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