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A research in Diabetes, Weight problems and Metabolism has recognized sure traits that may affect individuals’s weight reduction after taking pharmaceuticals known as glucagon-like peptide-1 receptor agonists (GLP-1RAs), reminiscent of semaglutide (offered beneath the model names Ozempic and Wegovy).
After analyzing knowledge on 679 sufferers with obese or weight problems who initiated GLP-1RAs between November 2022 and October 2024, investigators discovered that longer durations of GLP-1RA remedy, utilizing semaglutide, not having diabetes, and having the next share of physique fats have been related to higher weight discount over 12 months.
Increased metabolic price, skeletal muscle mass, muscle mass of the stomach and limbs, and serum creatinine have been additionally related to higher chances of profitable weight reduction.
“These findings may provide novel insights into the weight fluctuations after GLP-1RA treatment in the real-world setting, thereby advancing the development of individualized strategies with GLP-1RA therapy for patients with overweight or obesity,” mentioned co–corresponding creator Linong Ji, MD, of Peking College Folks’s Hospital, in Beijing.
Extra data:
Jingxuan Wang et al. Glucagon-like peptide-1 receptor agonist remedy related weight fluctuation and influencing components in sufferers with obese or weight problems, Diabetes Weight problems and Metabolism (2025). DOI: 10.1111/dom.16552
Quotation:
Which components have an effect on the success of in style prescription weight reduction medication in people? (2025, July 9)
retrieved 9 July 2025
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