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Anti-obesity medicines can considerably increase testosterone ranges and enhance well being outcomes for males with weight problems or kind 2 diabetes, in accordance with a brand new examine being introduced Monday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
Testosterone not solely performs a important function within the physique relating to male sexual functioning, however it may possibly additionally have an effect on a person’s bone mass, fats distribution, muscle mass, power and crimson blood cell manufacturing. Will increase in physique weight and prevalence of kind 2 diabetes are sometimes related to lowered testosterone ranges, leading to fatigue, decreased libido and high quality of life.
“While it is well known that weight loss from lifestyle changes or bariatric surgery increases testosterone levels, the impact that anti-obesity medications may also have on these levels has not been widely studied,” stated Shellsea Portillo Canales, M.D., endocrinology fellow at SSM Well being St. Louis College Hospital in St. Louis, Mo. “Our study is among the first to provide compelling evidence that low testosterone can be reversed with the use of commonly prescribed anti-obesity medications.”
To check this speculation, researchers analyzed the digital well being data of 110 grownup males with weight problems or kind 2 diabetes being handled with the weight-loss medicines semaglutide, dulaglutide or tirzepatide and who weren’t on testosterone or hormonal remedy. Contributors’ whole and free testosterone ranges have been measured earlier than and through remedy over the course of 18 months.
Together with 10% weight reduction, the proportion of males with regular ranges of each whole and free testosterone rose from 53% to 77%. These findings point out that anti-obesity medicines also can have a constructive impact on the reproductive well being of males with weight problems or kind 2 diabetes.
“Results from this study show that there is a direct correlation between the use of anti-obesity medications and testosterone levels,” stated Portillo Canales. “Doctors and their patients can now consider this class of medications not only for the treatment of obesity and to control blood sugar, but also to benefit men’s reproductive health.”
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Anti-obesity medicines can normalize testosterone ranges in males (2025, July 14)
retrieved 14 July 2025
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