In a examine printed within the August situation of the American Journal of Ophthalmology, diagnostic indicators are recognized for confirming power neuropathic ocular ache (NOP) for sufferers experiencing power dry eye (DE) after laser-assisted in situ keratomileusis (LASIK).
In a potential cross-sectional comparability examine, Amanda Vázquez, Ph.D., from the Institute of Utilized Ophthalmobiology on the Universidad de Valladolid in Spain, and colleagues in contrast the scientific traits of sufferers who developed each DE and NOP after LASIK to these with solely DE and to asymptomatic LASIK sufferers. The examine included 89 sufferers: 34 developed NOP and DE, 25 developed solely DE, and 30 had been asymptomatic controls.
The researchers discovered that sufferers within the NOP-DE group exhibited considerably extra DE signs with the Modified Single-Merchandise Dry Eye Questionnaire, a better stage of ache with the Numerical Ranking Scale and Wong-Baker Faces Ache Ranking Scale, elevated use of ocular lubrication, larger frequency of pathological outcomes on anxiousness and melancholy questionnaires, and a better prevalence of central sensitization syndromes in contrast with the DE group.
Increased tactile corneal sensitivity was additionally demonstrated by NOP-DE sufferers after topical anesthesia. In contrast with DE sufferers with out NOP, DE-NOP sufferers had decrease nerve density on in vivo confocal microscopy and better microneuroma density within the sub-basal nerve plexus. Average-to-strong correlations had been seen for many nerve metrics with scientific parameters.
“Our study revealed that higher post-topical anesthesia corneal tactile sensitivity, lower nerve density and higher microneuromas density in the sub-basal corneal nerve plexus are signs that can help diagnose NOP in patients suffering from DE and pain after refractive surgery,” the authors write.
Two authors disclosed ties to the biopharmaceutical business.
Extra info:
Amanda Vázquez et al, Corneal Sensory Adjustments and Nerve Plexus Abnormalities in Persistent Neuropathic Ocular Ache and Dry Eye Postrefractive Surgical procedure, American Journal of Ophthalmology (2025). DOI: 10.1016/j.ajo.2025.04.004
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Indicators of neuropathic ocular ache recognized after LASIK (2025, July 22)
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