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New analysis from investigators at Mass Normal Brigham suggests {that a} generally used kind 2 diabetes treatment is linked to the next charge of heart-related situations in comparison with drugs that hit different targets. The examine examined nationwide knowledge from practically 50,000 sufferers handled with completely different sulfonylureas and located that glipizide—essentially the most broadly used drug within the U.S. inside this class—was linked to increased incidence of coronary heart failure, associated hospitalization and loss of life in comparison with dipeptidyl peptidase-4 (DPP-4) inhibitors. Outcomes are revealed in JAMA Community Open.
“Patients with type 2 diabetes are at heightened risk of adverse cardiovascular incidents such as stroke and cardiac arrest,” mentioned corresponding writer Alexander Turchin, MD, MS, of the Division of Endocrinology at Brigham and Ladies’s Hospital (BWH), a founding member of the Mass Normal Brigham well being care system.
“While sulfonylureas are popular and affordable diabetes medications, there is a lack of long-term clinical data on how they affect cardiac health in comparison to more neutral alternatives like dipeptidyl peptidase 4 inhibitors.”
Turchin and co-authors emulated a goal trial by analyzing digital well being information and insurance coverage claims knowledge from the BESTMED consortium. The cohort included 48,165 sufferers with kind 2 diabetes and average cardiovascular threat who acquired care at 10 completely different examine websites throughout the nation, together with BWH, in addition to these coated by two completely different nationwide medical insurance plans.
The researchers studied the five-year threat of main adversarial cardiovascular occasions in sufferers handled with completely different sulfonylureas (glimepiride, glipizide or glyburide) or DPP4i along with metformin, a major diabetes treatment. They discovered that glipizide was related to a 13% enhance in cardiovascular threat when in comparison with DPP4i, whereas glimepiride and glyburide led to comparatively smaller and fewer clear results, respectively. The authors suggest that additional analysis is required to uncover the underlying mechanisms.
“Our study underscores the importance of evaluating each drug in a particular pharmacologic class on its own merits,” mentioned Turchin.
Extra data:
Cardiovascular Occasions in People Handled With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.23067
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Mass Normal Brigham
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Widespread kind 2 diabetes medication in contrast—examine finds increased cardiovascular threat for glipizide (2025, July 24)
retrieved 24 July 2025
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