A affected person with biochemical recurrence after radical prostatectomy and no pathological PSMA uptake within the PSMA PET/CT. The sufferers underwent salvage radiotherapy with passable response. Credit score: HD Zacho and AW Mogensen et al., Aalborg College Hospital, Aalborg, Denmark
A examine from Denmark reveals for the primary time that males with biochemically recurrent prostate most cancers who bear PSMA PET/CT earlier than salvage radiotherapy have improved survival charges in comparison with those that don’t.
Utilizing knowledge collected nationwide over a interval of eight years, researchers confirmed that PSMA PET/CT is a helpful device for figuring out sufferers who’re more likely to profit from salvage radiotherapy. This analysis is revealed within the August subject of The Journal of Nuclear Medication.
Biochemical recurrence after radical prostatectomy happens in as much as 40% of prostate most cancers sufferers and salvage radiotherapy is advisable as the primary healing choice. With salvage radiotherapy, physicians depend on imaging to exactly find recurrences for focused remedy. Whereas this imaging was beforehand carried out with bone scintigraphy, CT, or MRI, the superb diagnostic functionality of PSMA PET/CT makes it the present modality of alternative.
“It is widely accepted that PSMA PET/CT is more accurate than other imaging methods for returning prostate cancer, and that it often changes patient treatment strategies,” stated Anna W. Mogensen, MSc, a Ph.D. pupil on the Division of Nuclear Medication at Aalborg College Hospital in Aalborg, Denmark. “Nevertheless, it has remained unclear whether PSMA PET/CT-guided changes in treatment strategy led to improved survival.”
She continued, “PSMA PET/CT was launched in Denmark in 2015; nonetheless, not all areas adopted the imaging modality without delay. Using Denmark’s nationwide well being registry, my colleagues and I compiled a big and complete dataset to match the general survival between sufferers who underwent PSMA PET/CT earlier than salvage radiotherapy and people who didn’t.
The examine used knowledge obtained from routine medical follow of all sufferers handled with salvage radiotherapy in Denmark from 2015 by 2023. In whole, 844 sufferers have been categorized in response to whether or not they underwent pretreatment PSMA PET/CT (308 sufferers) or didn’t (536 sufferers). Researchers in contrast the general survival, in addition to biochemical recurrence-free survival, for as much as 5 years after completion of salvage radiotherapy.
The evaluation revealed better total survival for sufferers who underwent PSMA PET/CT earlier than salvage radiotherapy than for sufferers who didn’t. The one-, two-, and five-year survival charges for PSMA PET/CT sufferers have been 100, 99.5, and 98.1%, respectively, versus 99, 97.8, and 93.8%, respectively, for non-PSMA PET/CT sufferers. The three-year biochemical recurrence-free survival fee was in keeping with total survival: 74.9% for PSMA PET/CT sufferers and 69.4% for non-PSMA PET/CT sufferers.
“Our findings show that PSMA PET/CT scans can help clinicians select the patients most likely to experience success with salvage radiotherapy. This means fewer patients may receive unnecessary treatment, while more will be provided with the appropriate care,” Mogensen stated.
“These findings support the broader use of nuclear medicine techniques to guide therapy and suggest that integrating imaging early in treatment decisions could become a new standard in cancer care.”
Extra data:
Anna W. Mogensen et al, The Use of PSMA PET/CT Improves Total Survival in Males with Biochemically Recurrent Prostate Most cancers Handled with Salvage Radiotherapy: Actual-World Knowledge from an Total Nation, Journal of Nuclear Medication (2025). DOI: 10.2967/jnumed.125.269996
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Specialised imaging improves total prostate most cancers survival by figuring out advantages of salvage radiotherapy (2025, August 13)
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