Two doses of recombinant zoster vaccine (RZV) are related to a decreased danger for herpes zoster ophthalmicus (HZO), acute myocardial infarction, and stroke amongst adults aged 50 years or older, in response to a examine printed on-line Aug. 9 in Medical Infectious Ailments.
Emily Rayens, Ph.D., M.P.H., from Kaiser Permanente Southern California in Pasadena, and colleagues performed a matched cohort evaluation of adults aged 50 years and older who obtained two doses of RZV 4 weeks to 6 months aside throughout April 1, 2018, to Dec. 31, 2020, and had been matched in a 1:4 ratio with RZV-unvaccinated people. Information had been included for 102,766 two-dose RZV-vaccinated adults and 411,064 unvaccinated adults.
The researchers discovered that when evaluating RZV-vaccinated and unvaccinated people, the adjusted hazard ratios of HZO, hospitalized acute myocardial infraction, and hospitalized stroke had been 0.271, 0.720, and 0.575, respectively. In opposition to HZO, the adjusted RZV effectiveness was 72.9%.
“These data suggest that health benefits of RZV immunization may extend beyond the well-described prevention of herpes zoster and postherpetic neuralgia,” the authors write.
A number of authors disclosed ties to biopharmaceutical firms, together with GSK, which funded the examine.
Extra info:
Emily Rayens et al, Adjuvanted recombinant zoster vaccine is efficient in opposition to herpes zoster ophthalmicus, and is related to decrease danger of acute myocardial infarction and stroke in adults aged ≥50 years, Medical Infectious Ailments (2025). DOI: 10.1093/cid/ciaf440
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Two doses of zoster vaccine cut back danger for herpes zoster ophthalmicus (2025, August 19)
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