Consumption of low- and no-calorie sweeteners (LNCSs) is related to sooner cognitive decline, in response to a research printed on-line Sept. 3 in Neurology.
Natalia Gomes Gonçalves, Ph.D., from the Universidade de São Paulo in Brazil, and colleagues examined the affiliation between LNCS consumption and cognitive decline in a longitudinal observational research utilizing information from civil servants aged 35 years and older at baseline who have been enrolled within the Brazilian Longitudinal Research of Grownup Well being. Mixed and particular person consumption of seven LNCSs was calculated utilizing a Meals Frequency Questionnaire.
The imply LNCS consumption was 92.1 ± 90.1 mg/day amongst 12,772 members. The researchers discovered that in eight years of follow-up, consumption of mixed LNCSs within the highest tertiles was related to a sooner decline in verbal fluency and international cognition amongst members aged youthful than 60 years. Amongst members aged 60 years and older, no affiliation was seen between tertiles of LNCSs and cognitive decline. A sooner decline in international cognition, notably in reminiscence and verbal fluency domains, was seen in affiliation with consumption of aspartame, saccharin, acesulfame ok, erythritol, sorbitol, and xylitol. Consumption of mixed LNCSs within the highest tertiles was related to a sooner decline in verbal fluency and international cognition and with a sooner decline in reminiscence and international cognition amongst people with out and with diabetes, respectively.
“Low- and no-calorie sweeteners are often seen as a healthy alternative to sugar; however, our findings suggest certain sweeteners may have negative effects on brain health over time,” coauthor Claudia Kimie Suemoto, M.D., Ph.D., additionally from the Universidade de São Paulo, stated in a press release.
Extra data:
Natalia Gomes Gonçalves et al, Affiliation Between Consumption of Low- and No-Calorie Synthetic Sweeteners and Cognitive Decline, Neurology (2025). DOI: 10.1212/WNL.0000000000214023
Thomas Monroe Holland, The Darkish Aspect of Candy, Neurology (2025). DOI: 10.1212/WNL.0000000000214129
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Consumption of low-, no-calorie sweeteners tied to sooner cognitive decline (2025, September 7)
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