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Regardless of proof suggesting the security of hormone remedy for sufferers with a historical past of low-grade endometrial or epithelial ovarian most cancers, a brand new survey reveals that many gynecologists and a few gynecologic oncologists are nonetheless uncomfortable prescribing the remedy for this affected person inhabitants. This means a necessity for extra clinician schooling to assist overcome lingering misconceptions.
Survey outcomes are revealed on-line in Menopause within the article “Estrogen therapy in patients with gynecologic cancer: a survey of gynecologists and oncologists in the United States”.
Though most sufferers with gynecologic cancers are postmenopausal, it’s estimated that 40% of those sufferers are premenopausal or perimenopausal on the time of prognosis. Many sufferers present process surgical procedure for a gynecologic malignancy would require a bilateral oophorectomy as a part of their remedy. As well as, each chemotherapy and radiotherapy put girls prone to decreased ovarian operate.
Due to enhancements in most cancers therapies, it is very important think about the long-term results of major ovarian insufficiency and hormone deprivation in premenopausal sufferers with gynecologic most cancers. Estrogen remedy, nonetheless, has traditionally been underused on this inhabitants due to supplier issues primarily concerning most cancers recurrence.
In 2020, the Society of Gynecologic Oncology (SGO) launched a press release that was affirmed by The Menopause Society to assist information using hormone remedy in sufferers with gynecologic most cancers. Since that point, there is no such thing as a recognized publication of statistics relative to the impact on the frequency of practitioners prescribing hormones for this inhabitants.
That is why this new web-based survey of 293 members of the SGO and the American School of Obstetricians and Gynecologists was undertaken to discover and outline using estrogen remedy in girls with a historical past of gynecologic most cancers.
Among the highlighted outcomes of the survey embody
63.82% of respondents prescribe estrogen remedy to sufferers with endometrial most cancers
65.19% of respondents really feel comfy prescribing estrogen to sufferers with epithelial ovarian most cancers
96.8% of respondents are comfy prescribing estrogen for sufferers with cervical most cancers
Prescribing patterns differed considerably based mostly on intercourse, job title, and years in observe. The information counsel that benign gynecology care professionals and people with much less medical expertise usually tend to maintain misconceptions round hormone security.
The respondents have been additionally requested about their most popular estrogen remedy options. Selective serotonin reuptake inhibitors have been essentially the most often chosen (88.4%), adopted by gabapentin (58%), and neurokinin-3 antagonists (46.4%).
Research show that hormone remedy is a extremely efficient and protected (for most ladies) remedy to handle bothersome menopause signs that may significantly have an effect on a lady’s high quality of life. The most typical motive for not prescribing estrogen remedy in sufferers with a historical past of gynecologic most cancers was the assumption that the dangers outweighed the advantages. Though this can be true for sure cancers, it isn’t for all.
“Treatment for gynecologic cancers often accelerates the onset of menopause and contributes to more severe symptoms in this population. Hormone therapy is the most effective treatment for the management of vasomotor symptoms and genitourinary syndrome of menopause. Recognizing when hormone therapy can be safely used will have a beneficial effect on overall well-being and health,” says Dr. Monica Christmas, affiliate medical director for The Menopause Society.
Extra info:
Jamie L. McDowell, et al. Estrogen remedy in sufferers with gynecologic most cancers: a survey of gynecologists and oncologists in the US, Menopause (2025). DOI: 10.1097/GME.0000000000000002643
Supplied by
The North American Menopause Society
Quotation:
Misconceptions hold some most cancers affected person populations from benefiting from hormone remedy, survey reveals (2025, September 10)
retrieved 10 September 2025
from https://medicalxpress.com/information/2025-09-misconceptions-cancer-patient-populations-benefiting.html
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