Credit score: Intestine (2025). DOI: 10.1136/gutjnl-2025-334911
Researchers from Nationwide Taiwan College Hospital and Academia Sinica have recognized a easy blood marker that may reliably pinpoint power hepatitis B (CHB) sufferers at negligible danger of creating liver most cancers.
The research, revealed in Intestine, reveals that sufferers with hepatitis B floor antigen (HBsAg) ranges under 100 IU/mL face an annual hepatocellular carcinoma (HCC) danger of solely 0.08%, akin to the final inhabitants.
The findings come from two of the world’s largest HBV cohorts, ERADICATE-B and REVEAL-HBV, with greater than 2,600 inactive CHB sufferers adopted for over 25 years. Validation within the NTUH-iMD cohort confirmed that the low-risk threshold applies broadly.
Notably, about one-third (37%) of inactive CHB sufferers had HBsAg
“HBsAg liver cancer surveillance, which could transform public health strategies.”
Globally, 254 million individuals dwell with CHB, and over 1 million die yearly, primarily from HCC. Present surveillance protocols are expensive and sometimes burdensome, particularly in resource-limited settings. By adopting HBsAg
The authors emphasize that this threshold might additionally function a sensible endpoint for upcoming HBV treatment trials, bridging the hole between present antiviral remedy and useful treatment.
Extra info:
Tai-Chung Tseng et al, Hepatitis B floor antigen stage identifies sufferers with inactive power hepatitis B from Asia with HCC danger under surveillance threshold, Intestine (2025). DOI: 10.1136/gutjnl-2025-334911
Supplied by
Nationwide Taiwan College
Quotation:
Low hepatitis B floor antigen ranges sign minimal liver most cancers danger, redefining ‘partial treatment’ (2025, September 12)
retrieved 12 September 2025
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