Areas used to measure facial quantity and corresponding injection areas. LPJ, decrease perioral plus jawline; MEM, malars plus prolonged midface; UP, higher perioral. Credit score: Plastic & Reconstructive Surgical procedure (2025). DOI: 10.1097/prs.0000000000012135
Preliminary and follow-up 3D digital scans present new insights into the results of hyaluronic acid (HA) fillers in restoring facial quantity and fullness, stories a examine within the October difficulty of Plastic and Reconstructive Surgical procedure.
“Our study combines objective measurements of volumetric effects with patient satisfaction and other subjective outcomes to provide a deeper understanding of the immediate and long-term course of improvement after treatment with HA fillers,” feedback senior writer and ASPS Member Surgeon Ivona Percec, MD, Ph.D., of College of Pennsylvania, Philadelphia.
Facial volumes after HA filler injection: Rapid and follow-up measurements
Injectable dermal fillers are broadly used for sufferers searching for a younger look—decreasing facial traces and wrinkles and restoring aging-related lack of tissue quantity. Hyaluronic acid merchandise are the preferred fillers, with greater than 5.3 million procedures carried out in 2024, in keeping with ASPS statistics.
Though research have proven good enchancment with HA fillers, there are restricted knowledge on long-term modifications in facial quantity or affected person perceptions of remedy outcomes. To handle these gaps, Dr. Percec and colleagues evaluated goal and subjective outcomes of HA filler injection.
The researchers used superior three-dimensional scanning expertise (Vectra M3 imaging system) to measure fast and long-term modifications in tissue volumes. As well as, a variety of patient-reported outcomes—together with facial look and high quality of life—have been evaluated utilizing the validated FACE-Q questionnaire.
The examine included 101 girls, aged 40 to 65 years, present process HA filler injections for facial rejuvenation. Three formulations of HA filler have been utilized in completely different areas of the face. The 3D scans have been carried out instantly earlier than and after remedy and at two to 12 weeks’ follow-up to evaluate volumetric results (will increase in tissue quantity) in eight areas of the face.
‘HA fillers obtain affected person satisfaction a minimal of 12 weeks following remedy’
Based mostly on a measure referred to as tissue displacement issue (TDF), the scans confirmed fast enhance in facial quantity after HA filler injection, starting from 125% to 56%. These results lessened as preliminary swelling and irritation resolved. By two weeks, the efficient quantity (EV) was about 90% for HA injections within the decrease and center face and 70% within the lips.
At 12 weeks, quantity upkeep was about 66% in the entire face, starting from 79% within the midface, together with the cheeks; to 63% within the higher perioral area, together with the “marionette lines” between the nostril and lips; and 37% within the lips.
Corresponding FACE-Q responses confirmed significant enhancements in patient-reported outcomes. Along with subjective enhancements in general look and within the particular facial areas handled, sufferers reported beneficial properties in psychological and social functioning.
Quantity upkeep was affected by components together with age, historical past of smoking, and physique mass index. “These and other patient-specific variables contribute significantly to the outcomes of HA gel injections, requiring individual assessment.” Dr. Percec notes.
The target measurements present new info on the fast and long-term volumetric results of HA filler injection. The 2-week follow-up outcomes appear to mirror “the final effective clinical volume,” in keeping with the authors. The variations between facial areas possible mirror the higher quantity loss in areas with “greater animation,” notably the lips; in addition to the bodily properties of the smaller-particle HA filler product designed to be used within the lips.
The FACE-Q knowledge on patient-reported outcomes add to earlier research displaying “HA fillers’ capacity to achieve patient satisfaction a minimum of 12 weeks following treatment,” Dr. Percec and co-authors conclude. They imagine the target knowledge on volumetric results—notably the TDF and EV, reflecting preliminary and ultimate modifications in facial volumes—”should be consistently applied during treatment selection and patient counseling to optimize clinical outcomes and expectations.”
Extra info:
Harrison D. Davis et al, A Giant Potential Volumetric and Affected person-Reported Consequence Evaluation of Hyaluronic Acid Facial Fillers, Plastic & Reconstructive Surgical procedure (2025). DOI: 10.1097/prs.0000000000012135
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Volumetric examine exhibits goal results of hyaluronic acid filler injections (2025, September 26)
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