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Most sufferers receiving chemotherapy with taxanes or platinum salts develop ache and lack of sensitivity of their arms and ft—a extreme aspect impact that may intrude with correct remedy. Addressing this unmet medical want, researchers on the Institute of Analysis, Improvement and Innovation in Well being Biotechnology of Elche (IDiBE) at Miguel Hernández College (UMH) have coordinated a world medical trial demonstrating the effectiveness of an progressive topical cream developed at UMH to alleviate these signs and enhance most cancers sufferers’ high quality of life.
As much as 80% of sufferers handled with all these chemotherapy expertise hand–foot neuropathy, an hostile impact that will power dose discount and even remedy interruption. IDiBE-UMH professors Asia Fernández Carvajal and Antonio Ferrer Montiel coordinated this multicenter medical trial, which confirms that topical utility can considerably cut back the incidence of neuropathy within the arms and delay the onset of signs throughout remedy.
The research, printed within the journal Scientific and Translational Oncology, was performed in 9 hospitals throughout Spain and Belgium, involving 142 sufferers with most cancers. The trial in contrast a standard moisturizing cream with a nociceutical formulation developed at UMH and marketed by the spin-off firm Prospera Biotech.
Outcomes present a discount within the incidence of hand neuropathy, a delay within the onset of neuropathic signs throughout chemotherapy, and, total, a decrease impression of those signs on sufferers’ every day lives. These findings pave the way in which for brand new well being care choices to deal with an hostile impact that, till now, lacked efficient preventive remedies.
“Before the development of this formulation, oncologists and patients had no specific product to relieve these symptoms, which were often so severe that they led to dose reduction or even treatment discontinuation—with consequences for tumor control,” explains UMH Professor Asia Fernández Carvajal. In line with the researcher, the speed of dose discount or remedy abandonment in sufferers with peripheral neuropathy can attain as much as 60%.
For his half, UMH Professor Ferrer Montiel explains that the substances of the cream “protect sensory nerve endings in the skin, which are responsible for discomfort and itching in the peripheral neurosensory system.” On this manner, topical safety helps cut back hypersensitivity in arms and ft and improves tolerance to chemotherapy.
The product is at the moment obtainable in European pharmacies as a neurocosmetic—a protected and, on this case, additionally efficient product that can be utilized and not using a prescription.
“Moving into clinical trials is not easy, but we believe the effort is worthwhile if it allows this formulation to become an adjuvant during chemotherapy and after treatment, supporting the ongoing care of cancer patients,” concludes Ferrer Montiel.
Extra data:
Sonia Servitja et al, A topical nociceutical formulation ameliorates chemotherapy-induced peripheral neuropathy: a pilot randomized medical research, Scientific and Translational Oncology (2025). DOI: 10.1007/s12094-025-04062-1
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Miguel Hernandez College of Elche
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Topical cream calms chemotherapy unwanted side effects on the pores and skin in medical trial (2025, October 2)
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