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A research led by UCLA Well being Jonsson Complete Most cancers Heart investigators gives new proof that dietary modifications could assist scale back most cancers cell progress in sufferers present process lively surveillance, a remedy method that entails common monitoring of the most cancers with out quick intervention.
The findings, revealed within the Journal of Medical Oncology, present {that a} weight loss program low in omega-6 and excessive in omega-3 fatty acids, mixed with fish oil dietary supplements, considerably decreased the expansion charge of prostate most cancers cells in males with early-stage illness.
“This is an important step toward understanding how diet can potentially influence prostate cancer outcomes,” stated Dr. William Aronson, Professor of Urology on the David Geffen Faculty of Medication at UCLA and first creator of the research.
“Many men are interested in lifestyle changes, including diet, to help manage their cancer and prevent the progression of their disease. Our findings suggest that something as simple as adjusting your diet could potentially slow cancer growth and extend the time before more aggressive interventions are needed.”
Many males with low-risk prostate most cancers select lively surveillance over quick remedy. Nevertheless, inside 5 years, about 50% of those males ultimately have to endure remedy with both surgical procedure or radiation. Due to this, sufferers are keen to seek out methods to delay the necessity for remedy, together with by dietary modifications or dietary supplements.
Particular dietary tips on this space have but to be established. Whereas different medical trials have checked out rising vegetable consumption and nutritious diet patterns, none have discovered a major influence on slowing most cancers development.
To find out whether or not weight loss program or dietary supplements can play a job in managing prostate most cancers, the UCLA-led workforce carried out a potential medical trial, referred to as CAPFISH-3, that included 100 males with low threat or favorable intermediate threat prostate most cancers who selected lively surveillance. Contributors had been randomly assigned to both proceed their regular weight loss program or observe a low omega-6, excessive omega-3 weight loss program, supplemented with fish oil, for one 12 months.
Contributors within the intervention arm acquired dietary customized counseling from a registered dietitian nutritionist, both in-person, by telehealth or by cellphone. Sufferers had been guided on more healthy, decrease fats alternate options for top fats/excessive calorie meals (comparable to utilizing olive oil or lemon and vinegar for salad dressing), and on lowering consumption of meals with increased omega-6 content material (comparable to, chips, cookies, mayonnaise and different fried or processed meals).
The aim was to create a positive stability of their consumption of omega-6 and omega-3 fat and make individuals really feel empowered to manage how they modify their conduct. They had been additionally given fish oil capsules for further omega-3s. The management group didn’t get any dietary counseling or take fish oil capsules.
The researchers tracked modifications in a biomarker referred to as the Ki-67 index, which signifies how briskly most cancers cells are multiplying—a key predictor of most cancers development, metastasis and survival.
Similar website biopsies had been obtained firstly of the research and once more after the one-year mark, utilizing a picture fusion machine that helps observe and find the most cancers websites.
Outcomes confirmed that the low omega-6, omega-3 wealthy weight loss program and fish oil group had a 15% lower within the Ki-67 index, whereas the management group noticed a 24% improve.
“This significant difference suggests that the dietary changes may help slow cancer growth, potentially delaying or even preventing the need for more aggressive treatments,” stated Aronson, who can also be the Chief of urologic oncology on the West Los Angeles Veterans Affairs Medical Heart and member of the UCLA Well being Jonsson Complete Most cancers Heart.
Whereas the outcomes are promising, researchers didn’t discover any variations in different most cancers progress markers, comparable to Gleason grade, that are generally used to trace prostate most cancers development.
The investigators warning that additional analysis is important to substantiate the long-term advantages of omega-3 fatty acids and reducing omega-6 in managing prostate most cancers. The findings help additional, bigger trials to discover the long-term influence of dietary modifications on most cancers development, remedy outcomes and survival charges in males on lively surveillance.
Extra info:
Journal of Medical Oncology
Offered by
College of California, Los Angeles
Quotation:
A low omega-6, omega-3 wealthy weight loss program and fish oil could gradual prostate most cancers progress (2024, December 13)
retrieved 13 December 2024
from https://medicalxpress.com/information/2024-12-omega-rich-diet-fish-oil.html
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