Impact of DMT on infarct dimension and barrier integrity in a rat mannequin of stroke. Credit score: Science Advances (2025). DOI: 10.1126/sciadv.adx5958
DMT, or dimethyltryptamine, is a pure psychoactive molecule discovered in lots of vegetation and mammals. In line with an article revealed in Science Advances, researchers from the HUN-REN BRC Institute of Biophysics and Semmelweis College Coronary heart and Vascular Middle discovered that DMT reduces the dangerous results of stroke in animal fashions and cell tradition experiments.
DMT can also be current within the human mind, and it’s at present present process scientific trials to assist restoration of mind operate after stroke. Nonetheless, its precise mechanism of motion had not been absolutely understood till now. “It is amazing how we can always turn to nature to find ingenious solutions for health problems,” says co-lead creator Mária Deli from the HUN-REN BRC.
“We found that DMT significantly reduced infarct volume and edema formation in a rat stroke model,” explains co-first creator Marcell László.
In each animal experiments and cell tradition fashions, the authors confirmed that DMT therapy restored the construction and performance of the broken blood-brain barrier and improved the operate of astroglial cells. This psychoactive compound additionally inhibited the manufacturing of inflammatory cytokines in mind endothelial cells and peripheral immune cells, whereas decreased the activation of mind microglia cells via Sigma-1 receptors.
“The therapeutic options currently available for stroke are very limited. The dual action of DMT, protecting the blood-brain barrier while reducing brain inflammation, offers a novel, complex approach that could complement existing treatments,” says Judit Vigh, co-first creator of the work.
Since present stroke therapies don’t at all times end in full restoration, a DMT-based therapy might characterize a promising new various, primarily together with current strategies. The latest findings from researchers in Szeged and Budapest, Hungary, help the event of a remedy that goes past the restrictions of typical stroke therapy. Medical trials on the usage of DMT and investigation on its long-term results are at present ongoing.
Extra info:
Marcell J. László et al, N,N-dimethyltryptamine mitigates experimental stroke by stabilizing the blood-brain barrier and lowering neuroinflammation, Science Advances (2025). DOI: 10.1126/sciadv.adx5958
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A pure compound towards stroke? Psychoactive agent protects mind vessels and reduces irritation (2025, September 26)
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