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NEW YORK DAWN™ > Blog > Health > A standard sleep assist blocks neurodegeneration in mice
A standard sleep assist blocks neurodegeneration in mice
Health

A standard sleep assist blocks neurodegeneration in mice

Last updated: May 28, 2025 7:14 pm
Editorial Board Published May 28, 2025
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A brand new examine by WashU Medication researchers means that lemborexant and sleep aids that work the identical manner may assist deal with or stop harm brought on by dangerous buildup of the protein tau in a number of neurodegenerative ailments, together with Alzheimer’s. Proven are cross-sections of mind tissue from two mice genetically susceptible to tau accumulation. Therapy with lemborexant (proper) ends in bigger quantity within the hippocampus (central purple spiral), vital for reminiscence, and a smaller hole in mind tissue (white area) in contrast with no remedy (left). Credit score: Samira Parhizkar/WashU Medication

A standard sleep assist restores more healthy sleep patterns and protects mice from the mind harm seen in neurodegenerative issues, resembling Alzheimer’s illness, in accordance with new analysis from Washington College Faculty of Medication in St. Louis. The drug, lemborexant, prevents the dangerous buildup of an irregular type of a protein known as tau within the mind, decreasing the inflammatory mind harm tau is understood to trigger in Alzheimer’s.

The examine means that lemborexant and different medication that work in the identical manner may assist deal with or stop the harm brought on by tau in a number of neurodegenerative ailments, together with Alzheimer’s, progressive supranuclear palsy, corticobasal syndrome and a few frontotemporal dementias.

The examine is revealed in Nature Neuroscience.

“We have known for a long time that sleep loss is a risk factor for Alzheimer’s disease,” mentioned senior writer David M. Holtzman, MD, the Barbara Burton and Reuben M. Morriss III Distinguished Professor of Neurology at WashU Medication.

“On this new examine, we’ve proven that lemborexant improves sleep and reduces irregular tau, which seems to be a most important driver of the neurological harm that we see in Alzheimer’s and a number of other associated issues. We’re hopeful this discovering will result in additional research of this sleep remedy and the event of latest therapeutics which may be simpler than present choices both alone or together with different accessible remedies.

“The antibodies to amyloid that we now use to treat patients with early, mild Alzheimer’s dementia are helpful, but they don’t slow the disease down as much as we would like,” he added. “We need ways to reduce the abnormal tau buildup and its accompanying inflammation, and this type of sleep aid is worth looking at further. We are interested in whether going after both amyloid and tau with a combination of therapies could be more effective at slowing or stopping the progression of this disease.”

Holtzman and his workforce have been among the many first to determine the connection between poor sleep as a threat issue for Alzheimer’s illness and the buildup of proteins resembling amyloid and tau. In previous work learning mice genetically susceptible to amyloid and tau buildup attribute of Alzheimer’s illness, they confirmed that sleep deprivation makes this buildup worse. Bettering sleep in these mice with lemborexant gave the impression to be protecting, the newest examine confirmed, with much less buildup of tau protein tangles and fewer nerve cell dying related to Alzheimer’s illness.

The protein tau accumulates within the mind in a number of neurological issues, together with Alzheimer’s, and causes irritation and the dying of mind cells. Holtzman and his workforce—co-led by first writer Samira Parhizkar, Ph.D., an teacher in neurology—examined lemborexant partially as a result of it has results on elements of the mind recognized to be affected by irregular tau accumulation. It additionally doesn’t impair motor coordination, which is a priority for individuals with dementia taking hypnotic sleep aids.

Lemborexant is one in every of three sleep medication authorised by the Meals and Drug Administration that inhibit the impact of orexins, small proteins that regulate sleep, by appearing as orexin receptor antagonists. Lemborexant blocks each orexin receptors (kind 1 and kind 2). Receptors are proteins on the cell floor that bind to different molecules and regulate cell exercise. These receptors are recognized to play vital roles in sleep-wake cycles and urge for food, amongst different physiological processes.

In mice genetically susceptible to dangerous tau buildup, lemborexant decreased mind harm in contrast with management mice. For instance, these receiving lemborexant confirmed a 30% to 40% bigger quantity within the hippocampus—part of the mind vital for forming recollections—in contrast with management mice and people receiving a distinct sleep drug, zolpidem, which belongs to a distinct class of medicine.

Zolpidem elevated sleep however had not one of the protecting results towards tau accumulation within the mind that have been seen with lemborexant, suggesting that the kind of sleep assist—orexin receptor antagonist—is essential in producing the neuroprotective results. The researchers additionally discovered that the useful results have been solely seen in male mice, which they’re nonetheless working to know.

Regular tau is vital in sustaining the construction and performance of neurons. When wholesome, it carries a small variety of chemical tags known as phosphate teams. However when tau picks up too many of those chemical tags, it may possibly clump collectively, resulting in irritation and nerve cell dying. The authors discovered that by blocking orexin receptors, lemborexant prevents extra tags from being added to tau, serving to tau preserve its wholesome roles within the mind.

Holtzman mentioned his workforce is constant to discover the explanations lemborexant remedy’s neuroprotective results have been seen solely in male mice. He speculated that the intercourse discrepancy could possibly be because of the commentary that feminine mice with the identical genetic predisposition to tau accumulation developed less-severe neurodegeneration in contrast with male mice. With much less harm to start with, the potential useful results of the drug may have been smaller and tougher to detect.

Extra data:
Samira Parhizkar et al, Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse mannequin of tauopathy, Nature Neuroscience (2025). DOI: 10.1038/s41593-025-01966-7

Offered by
Washington College in St. Louis

Quotation:
A standard sleep assist blocks neurodegeneration in mice (2025, Might 28)
retrieved 28 Might 2025
from https://medicalxpress.com/information/2025-05-common-aid-blocks-neurodegeneration-mice.html

This doc is topic to copyright. Aside from any honest dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.

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