Publicity to air air pollution could worsen bone loss in postmenopausal girls, based on a research printed on-line April 24 within the Journal of Bone and Mineral Analysis.
Diddier Prada, M.D., Ph.D., from the Institute for Well being Fairness Analysis on the Icahn College of Medication at Mount Sinai in New York Metropolis, and colleagues evaluated the metabolomic response to air pollution and its potential affect on bone well being in postmenopausal girls. The evaluation included members within the Ladies’s Well being Initiative (140 instances and 138 controls with out there information on air air pollution and bone mineral density).
The researchers discovered that in any respect averaging durations by means of 9 years, publicity to air air pollution could worsen bone loss in postmenopausal girls. Nitrogen oxide, nitrogen dioxide, and sulfur dioxide have been related to taurine, inosine, and C38:4 phosphatidylethanolamine, respectively. There was no affiliation seen for high quality particulate matter ≤10 μm. Within the affiliation between one-year common nitrogen oxide and lumbar backbone bone mineral density, there was partial potential mediation with C38:4 phosphatidylethanolamine.
“This isn’t just a scientific breakthrough; it’s a wake-up call for detecting early those at risk of bone damage,” Prada mentioned in an announcement. “Understanding these pathways could lead to therapeutic strategies to mitigate pollution-related bone damage, especially since avoiding exposure is often impossible.”
Extra data:
Diddier Prada et al, Metabolomic Analysis of Air Air pollution-related Bone Harm and Potential Mediation in Ladies’s Well being Initiative Individuals, Journal of Bone and Mineral Analysis (2025). DOI: 10.1093/jbmr/zjaf059
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Air air pollution could worsen bone well being in postmenopausal girls (2025, Could 16)
retrieved 16 Could 2025
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