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Older girls with bigger waist circumference could also be at a a lot higher danger of dying for any given BMI, based on worldwide analysis, which monitored girls over greater than twenty years. The research discovered that for post-menopausal girls aged 50–79, taking waist circumference into consideration together with BMI, higher mirrored the function weight problems performs within the danger of dying than utilizing BMI alone.
A potential cohort research discovered that stratifying BMI classes by BMI-specific waist circumference thresholds modestly improved mortality danger stratification in postmenopausal girls, with bigger waist circumference predicting higher mortality in girls throughout BMI teams.
The findings assist current Worldwide Atherosclerosis Society (IAS) and Worldwide Chair on Cardiometabolic Danger (ICCR) suggestions to incorporate waist circumference measurement with BMI in affected person screenings to determine high-risk weight problems phenotypes. The research is printed within the Annals of Inside Drugs. An Editorial and Abstract for Sufferers had been additionally printed in the identical difficulty.
Researchers from the Fred Hutchinson Most cancers Heart and colleagues analyzed knowledge for 139,213 postmenopausal girls aged 50 to 79 years from the Girls’s Well being Initiative, a multicenter, population-based research with enrollment from 1993 to 1998 and follow-up by way of 2021. The contributors had been divided into three cohorts: improvement cohort (67,774 contributors), Validation Cohort 1 (48,335 contributors with a excessive prevalence of obese or weight problems), and Validation Cohort 2 (23,104 contributors from various, geographically separate facilities).
Researchers developed three fashions to foretell mortality danger: a mortality mannequin; the mortality mannequin plus BMI (BMI mannequin); and the mortality mannequin plus BMI plus BMI-specific waist circumference thresholds (BMI-WC mannequin). BMI classes included regular weight, obese, and weight problems lessons 1 to three, and had been stratified by prespecified waist circumference thresholds of ≥80, ≥90, ≥105, ≥115, and ≥115 cm, respectively.
Validation Cohort 1 had a better prevalence of huge waist circumference (21.9%), based on BMI-specific waist thresholds, than Validation Cohort 2 (18.2%). Practically all girls with obesity-2 or obesity-3 had waist circumference of 88 cm or bigger—the present guideline for ladies and unbiased of BMI.
After stratification, the researchers discovered that mortality danger was higher for BMI classes with bigger waist circumference than their counterparts with regular waist circumference. Moreover, mortality danger was comparable for ladies with regular weight or obese and enormous waist circumference and ladies with obesity-1 and regular waist circumference.
General, stratifying BMI classes by waist circumference thresholds modestly improves danger stratification for all-cause mortality in wholesome postmenopausal girls with a excessive prevalence of obese or weight problems. These outcomes counsel that medical tips for assessing adiposity would profit from the incorporation of waist circumference with BMI measures.
Extra info:
Aaron Okay. Aragaki et al, Improvement and Validation of Physique Mass Index–Particular Waist Circumference Thresholds in Postmenopausal Girls, Annals of Inside Drugs (2025). DOI: 10.7326/ANNALS-24-00713
Christina C. Wee et al, Staging Weight problems Danger Past Physique Mass Index: Progress Made however Extra to Do, Annals of Inside Drugs (2025). DOI: 10.7326/ANNALS-25-02327
Abstract for Sufferers: Improvement and Validation of Physique Mass Index–Particular Waist Circumference Thresholds in Postmenopausal Girls, Annals of Inside Drugs (2025). DOI: 10.7326/ANNALS-24-00713-PS
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