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A examine in JDR Scientific & Translational Analysis demonstrates that arginine dentifrices scale back dental caries in youngsters with lively caries as successfully as or extra successfully than a sodium fluoride dentifrice, relying on the arginine focus.
Dental caries stay a big oral well being burden globally. Scientific proof has demonstrated the dose-dependent, anticaries motion of fluoride; nevertheless, more practical, complete, and different prevention methods needs to be investigated.
The examine, “Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial” by Wei Lin of Sichuan College and colleagues carried out a two-year, section III, double-blind, three-arm, parallel-group, randomized managed trial from April 15, 2019 via March 12, 2022 throughout three facilities in China.
Six thousand youngsters aged 10–14 with two or extra lively caries lesions had been assigned considered one of three examine dentifrices: 8.0% arginine, 1.5% arginine, and 0.32% NaF as a constructive management. The first efficacy outcomes had been incremental DMFS (decayed, lacking, and stuffed surfaces) and DMFT (decayed, lacking, and stuffed enamel) caries index scores after two years of product use.
After two years, the 8.0% arginine-containing dentifrice demonstrated a statistically vital 26.0% discount in DMFS and 25.3% in DMFT scores vs. the 0.32% NaF management. No statistical distinction was measured between the 1.5% arginine-containing dentifrice and the 0.32% NaF management in DMFS and DMFT.
This medical examine confirms that relying on the focus, arginine dentifrices are as efficient or more practical than a sodium fluoride dentifrice in offering anti-caries safety in youngsters with lively caries.
Extra info:
W. Yin et al, Arginine Dentifrices and Childhood Caries Prevention: A Randomized Scientific Trial, JDR Scientific & Translational Analysis (2025). DOI: 10.1177/23800844251361471
Supplied by
Worldwide Affiliation for Dental, Oral, and Craniofacial Analysis
Quotation:
Arginine dentifrices considerably scale back childhood caries, medical trial finds (2025, August 13)
retrieved 13 August 2025
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