Research design and flowchart. Credit score: Allergy (2025). DOI: 10.1111/all.16679
A randomized placebo-controlled Finnish research confirmed that aspirin remedy doesn’t present vital aid for individuals affected by power rhinosinusitis with nasal polyps who’re hypersensitive to non-steroidal anti-inflammatory medicine (NSAIDs). The outcomes of a joint research carried out by the College of Japanese Finland, College of Helsinki and HUS Irritation Heart had been printed within the journal Allergy.
Non-steroidal anti-inflammatory drug-exacerbated respiratory illness (N-ERD) sometimes includes hypersensitivity to anti-inflammatory medicine, bronchial asthma, and power rhinosinusitis with nasal polyps (CRSwNP). Nasal polyps are attributable to extra development of the nasal mucous membranes. Hospitals have been treating this dysfunction with long-term aspirin (ASA) remedy for roughly 15 years.
“ASA therapy is affordable, but there hasn’t been sufficient evidence of its effectiveness. Obtaining information on the effectiveness of treatment is important because several biologic medications currently available to treat the symptoms are effective but also very expensive,” says Professor Sanna Toppila-Salmi from the College of Japanese Finland, who led the research.
The research concerned administering aspirin desensitization remedy to 26 sufferers with N-ERD, bronchial asthma and extreme CRSwNP after which randomizing them into teams taking both aspirin or a placebo orally for 11 months.
“No differences in symptoms or lung function were found between the aspirin and placebo groups at the end of therapy. There were signs that ASA therapy could slightly reduce nasal polyps and improve quality of life related to nasal symptoms compared to a placebo, but the difference was not statistically significant,” says Doctoral Researcher Alma Helevä from the College of Helsinki.
There was additionally no distinction between the teams regarding what number of programs of cortisone had been wanted throughout exacerbation phases.
Primarily based on the outcomes, solely 25% of sufferers who obtained aspirin may very well be categorised as benefiting from the remedy, and 18% of sufferers within the aspirin group needed to cease the remedy on account of uncomfortable side effects. The uncomfortable side effects—akin to respiratory signs, worsening of bronchial asthma, belly signs or elevated bleeding tendency—occurred in 56% of the contributors who obtained aspirin, but additionally in 30% of those that obtained a placebo.
“Based on this study, ASA therapy did not have a significant effect compared to a placebo, and a significant number of patients also suffered adverse effects. A small number of patients benefited from the therapy, but at this time it is not possible to identify which patients who are hypersensitive to NSAIDs would benefit from ASA therapy,” acknowledged the researchers.
Extra info:
Alma Helevä et al, Efficacy of ASA Remedy After Desensitization on CRSwNP Sufferers With Bronchial asthma and N‐ERD—A Randomized Medical Trial, Allergy (2025). DOI: 10.1111/all.16679
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Aspirin remedy proves ineffective in treating power rhinosinusitis with nasal polyps (2025, September 8)
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