The long-term outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) might differ in intention-to-treat (ITT) and per protocol (PP) populations, in line with a research revealed on-line Feb. 19 in JAMA Surgical procedure.
Marko Kraljević, M.D., from the College Hospital of Basel in Switzerland, and colleagues in contrast long-term weight and metabolic outcomes, reoperation charges, and high quality of life for sufferers at 10 years and past within the Swiss Multicenter Bypass or Sleeve Examine randomized scientific trial. A complete of 217 sufferers had been enrolled and randomly assigned to SG or RYGB (107 and 110, respectively).
The researchers discovered that within the ITT inhabitants, the imply share extra physique mass index loss (percentEBMIL) was not considerably totally different between SG and RYGB (60.6 and 65.2, respectively). In contrast with RYGB, sufferers who underwent SG had considerably larger conversion charges attributable to inadequate weight discount or reflux (29.9 versus 5.5%).
After 10 years, within the PP inhabitants, sufferers present process RYGB had considerably larger imply percentEBMIL in contrast with these present process SG (65.9 versus 56.1%). Nonetheless, the teams didn’t considerably differ by way of imply share complete weight reduction (27.7 and 25.5% for RYGB and SG, respectively). Considerably extra de novo gastroesophageal reflux occurred in SG versus RYGB sufferers.
“For the ITT analysis, no significant difference in percentEBMIL was found after 10 years comparing SG and RYGB. However, the PP analysis revealed superior weight loss in patients who underwent RYGB compared to SG,” the authors write.
A number of authors disclosed ties to the pharmaceutical and medical machine industries.
Extra data:
Marko Kraljević et al, Lengthy-Time period Outcomes of Laparoscopic Roux-en-Y Gastric Bypass vs Laparoscopic Sleeve Gastrectomy for Weight problems, JAMA Surgical procedure (2025). DOI: 10.1001/jamasurg.2024.7052
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At 10 years, Roux-en-Y gastric bypass superior for affected person extra BMI loss (2025, February 24)
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