Visible summary of the revised STARS trial. Credit score: The College of Texas MD Anderson Most cancers Heart
Researchers from The College of Texas MD Anderson Most cancers Heart will current new information on the American Society for Radiation Oncology (ASTRO) 2025 Annual Assembly demonstrating that stereotactic physique radiation remedy (SBRT) and surgical procedure achieved related survival outcomes at 10-year follow-up for sufferers with early-stage non-small cell lung most cancers, with radiation providing quality-of-life advantages. These findings will probably be introduced Sept. 29 by Joe Chang, M.D., Ph.D., professor of Radiation Oncology, and Troy Kleber, M.D., resident.
At a median follow-up of 8.3 years, general survival charges had been 69% for the SBRT cohort and 66% for the surgical procedure cohort, a distinction that was not statistically important. Lung cancer-specific survival and recurrence-free survival charges additionally had been related. Though the information present the next acute complication fee brought on by surgical procedure, the quality-of-life survey for sufferers at 10 years was related. Chang and Kleber shared extra insights beneath.
What are the important thing findings being introduced?
“The most important finding is that SBRT and surgery had similar 10-year outcomes, reinforcing the initial five-year data that we have previously presented from this trial. This is very encouraging because we sometimes see similar outcomes at three years or even five years of follow-up that diverge over time. In this case, our initial findings continue to hold up after 10 years. There also are some notable advantages in quality of life for SBRT patients, including significantly fewer acute treatment-related complications,” Chang stated.
What are the benefits of SBRT over surgical procedure for sufferers?
“SBRT is a specific type of radiation therapy that precisely targets tumors with very high doses of radiation. It is also known as stereotactic ablative body radiation (SABR). The first major advantage is simply that many patients aren’t eligible for surgery for a variety of potential reasons. One factor is age, as many older patients are at much greater risk for complications with surgery, so a noninvasive option is immediately an advantage for those patients. Another advantage is an easier recovery process, so patients who are treated with SBRT generally have less financial strain than those who undergo surgery,” Kleber stated.
Does this point out that SBRT ought to be the choice for all early-stage non-small cell lung most cancers sufferers?
“No, but it does emphasize the importance of a multidisciplinary care team to consider all options for their patients. For example, for patients whose tumors are more complex, larger, or located in certain areas, surgery remains the best treatment option. This study confirms that SBRT is an effective alternative that should be considered,” Chang stated.
What strategies had been used within the examine?
This trial in contrast 80 sufferers who had been handled with SBRT to 80 who underwent surgical procedure. The enrolled sufferers had tumors smaller than three centimeters, no lymph node involvement and no distant metastases. The surgical group acquired video-assisted thoracoscopic (VATS) lobectomy and mediastinal lymph node elimination.
Extra info:
Chang, J. et al. SBRT Radiation Remedy vs. Surgical procedure for NSCLC at 10 years.
Supplied by
College of Texas M. D. Anderson Most cancers Heart
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At 10 years, stereotactic physique radiation remedy akin to surgical procedure for early-stage lung most cancers (2025, September 26)
retrieved 27 September 2025
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