In vitro coagulation efficiency of BC and T-BC dressings noticed 1 minute after blood software. Credit score: Superior Supplies (2025). DOI: 10.1002/adma.202420338
In a examine printed in Superior Supplies, a analysis staff developed an modern bacterial cellulose (BC)-based hemostatic dressing that permits fast and sustained bleeding management.
Burn accidents are a sort of extreme trauma, which regularly includes a number of organs, inflicting excessive morbidity and mortality. Throughout burn debridement, hemostasis management has lengthy been difficult. Conventional electrocautery is efficient for bleeding management, but it surely carries dangers similar to thermal tissue injury and it has operational limitations.
BC has emerged as a promising wound dressing materials as a consequence of its microporous construction, mechanical power, breathability, and biocompatibility. Nevertheless, BC lacks intrinsic bioactivity, particularly hemostatic properties, limiting its effectiveness in complicated wound conditions.
On this examine, the researchers, led by Dr. Zhong Chao and Dr. An Bolin from the Shenzhen Institute of Superior Know-how of the Chinese language Academy of Sciences, collaborating with Dr. Liu Yan from Ruijin Hospital Affiliated to Shanghai Jiao Tong College Faculty of Drugs, developed an artificial bioengineered answer.
By anchoring human-derived thrombin onto a BC matrix by way of a specialised cellulose-binding area (CBD), they created a thrombin-anchored BC (T-BC) composite dressing that permits fast hemostasis and promotes wound therapeutic. This answer preserves BC’s pure nanomesh construction, breathability, and biocompatibility, whereas enhancing its hemostatic properties by protein engineering.
In vitro coagulation efficiency of BC and T-BC dressings noticed 1 minute after blood software. Playback pace: 4×. Credit score: Superior Supplies (2025). DOI: 10.1002/adma.202420338
In vitro coagulation checks confirmed the dressing’s superior hemostatic efficiency. In a rat liver incision mannequin, the T-BC dressing achieved efficient hemostasis inside one minute, considerably outperforming typical supplies.
Furthermore, in a simulated deep second-degree burn wound mannequin, T-BC-treated wounds exhibited markedly accelerated therapeutic, with wound closure charges 40% larger than these of the management group after solely 5 days.
Genetic-level analyses revealed that the T-BC dressing accelerates wound therapeutic by a triple synergistic mechanism: selling neovascularization, modulating inflammatory responses, and facilitating the reconstruction of pores and skin tissue structure. This multi-faceted motion permits exact molecular regulation of the therapeutic course of.
The modern biomolecular self-assembly technique permits environment friendly thrombin immobilization by easy immersion in a light protein answer, eliminating the necessity for harsh chemical compounds or excessive circumstances usually related to chemical crosslinking. Complete biosafety evaluations, together with cytotoxicity, hemolysis, and histocompatibility checks, confirmed the fabric’s glorious biocompatibility and total security.
This work demonstrates important potential for future functions within the administration of each acute traumatic accidents and continual wounds.
Extra info:
Yaomin Wang et al, Thrombin‐Anchored Bacterial Cellulose Dressing for Superior Burn Wound Care, Superior Supplies (2025). DOI: 10.1002/adma.202420338
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Chinese language Academy of Sciences
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Bacterial cellulose-based dressing affords fast bleeding management for burn wound care (2025, August 2)
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