The danger for breast most cancers is elevated with weight acquire after age 35 years, in accordance with a analysis letter not too long ago revealed in Most cancers Biology & Drugs.
Katherine De la Torre, from the Seoul Nationwide College School of Drugs in South Korea, and colleagues carried out a potential research to look at the affiliation between weight change all through distinct lifetime intervals and breast most cancers danger stratified by menopausal standing. A complete of 73,192 Korean ladies (aged 40 to 69 years) have been prospectively adopted throughout a median follow-up of 9.2 years.
The researchers discovered 790 new breast most cancers instances amongst 66,870 ladies with info on weight at 35 years of age. Of those ladies, 10.72, 32.68, and 35.92 p.c had weight reduction, maintained steady weight, and gained >5.0 kg, respectively. In contrast with ladies with steady weight, those that gained >10 kg after 35 years of age had an elevated danger for breast most cancers (hazard ratio, 1.41).
Amongst premenopausal ladies, gaining 5 to 9.9 kg and ≥10 kg after 35 years of age elevated the danger for breast most cancers (hazard ratios, 1.89 and a pair of.23, respectively), with a dose-response impact. Ladies who gained >0.75 kg per 12 months after age 35 years had an elevated danger for breast most cancers when a linear weight increment was assumed (hazard ratio, 1.35), however there have been no associations primarily based on menopausal standing.
“Our research points to the critical period after age 35 as a potential window for weight management interventions aimed at breast cancer prevention,” lead creator Daehee Kang, M.D., Ph.D., additionally from Seoul Nationwide College Hospital, mentioned in an announcement.
Extra info:
Katherine De la Torre et al, Weight acquire after 35 years of age is related to elevated breast most cancers danger: findings from a big potential cohort research, Most cancers Biology & Drugs (2024). DOI: 10.20892/j.issn.2095-3941.2024.0172
Quotation:
Breast most cancers danger will increase with weight acquire after age 35, finds research (2024, December 18)
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