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A single dose of the long-acting antibody nirsevimab to infants can halve hospitalizations for bronchiolitis.
That is the results of a research involving the Università Cattolica del Sacro Cuore, Rome campus—Fondazione Policlinico Universitario Agostino Gemelli IRCCS, coordinated by Universitat Politècnica de Catalunya (UPC), Catalonia, Youngsters’s Emergency Division, Leicester Royal Infirmary and College of Edinburgh, the primary to investigate a “real world” case research.
Developed to stop respiratory syncytial virus infections, the drug has been authorized on the European degree to guard infants of their first season of publicity to the virus.
The work was revealed in The Lancet Regional Well being—Europe journal and was coordinated by Dr. Danilo Buonsenso, researcher in Common and Specialist Pediatrics on the College of Drugs of the Catholic College and pediatrician on the Pediatric Infectious Ailments Unit of the Fondazione Policlinico Gemelli IRCCS.
Buonsenso explains, “Now, for the first time, a real-world study has analyzed the concrete impact of nirsevimab by comparing European countries with different health policies: Catalonia (Spain), where the drug was introduced in 2023-2024, and some areas of the UK and Rome (Italy), where it had not yet been adopted.”
Bronchiolitis is an acute viral an infection that impacts the respiratory system of youngsters beneath one yr of age primarily within the first six months of life with higher frequency between November and March. It’s typically related to respiratory syncytial virus an infection (in about three out of 4 circumstances) that may trigger respiratory failure, particularly in kids beneath one yr of age and amongst infants beneath six months outdated.
However different viruses may also be the trigger: metapneumovirus, coronavirus, rhinovirus, adenovirus, influenza and parainfluenza viruses. An infection outcomes from transmission primarily by direct contact with contaminated secretions.
The information, collected from 68 Catalan hospitals and 5 hospitals in the UK and Italy, present a transparent consequence: in kids beneath 6 months in Catalonia, hospitalizations for bronchiolitis have virtually halved in comparison with the typical of earlier seasons.
Emergency room admissions for a similar age group have been additionally considerably decreased. In distinction, no important discount emerged within the different European facilities the place nirsevimab was not administered.
The drug’s impact was much less pronounced in older kids (between 6 and 23 months), suggesting that the best efficacy is concentrated within the first few months of life. The authors additionally emphasize the necessity for bigger, internationally coordinated research, not least to evaluate the financial sustainability of introducing nirsevimab on a big scale.
The research represents an essential step in assessing the true effectiveness of latest preventive methods in opposition to RSV, evaluating, for the primary time, international locations with completely different approaches to its implementation, Buonsenso concludes.
Extra info:
Actual-world influence of nirsevimab immunisation in opposition to respiratory illness on emergency division attendances and admissions amongst infants: a multinational retrospective evaluation, The Lancet Regional Well being – Europe (2025).
Supplied by
Catholic College of the Sacred Coronary heart
Quotation:
Bronchiolitis: Monoclonal antibody halves hospitalizations of youngsters youthful than 6 months outdated (2025, June 3)
retrieved 3 June 2025
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