For sufferers referred for peripherally inserted central catheters (PICCs), the danger for system failure just isn’t decrease with hydrophobic or chlorhexidine PICCs versus normal polyurethane ones, based on a examine revealed within the New England Journal of Drugs.
Amanda J. Ullman, Ph.D., from the College of Queensland in Brisbane, Australia, and colleagues carried out a randomized, managed, superiority trial in three tertiary hospitals involving adults and kids who have been referred for PICC placement. Contributors have been randomly assigned to obtain a hydrophobic or chlorhexidine PICC or a typical polyurethane PICC (365, 365, and 368, respectively) and have been adopted for eight weeks.
The researchers discovered that system failure occurred in 5.9, 9.9, and 6.1% of individuals within the hydrophobic, chlorhexidine, and normal polyurethane teams, respectively (danger distinction: hydrophobic versus normal polyurethane, −0.2 proportion factors [95% confidence interval, −3.7 to 3.2; P = 0.89]; chlorhexidine versus normal polyurethane, 3.8 proportion factors [95% confidence interval, −0.1 to 7.8; P = 0.06]).
The chances ratio for system failure was 0.96 (95% confidence interval, 0.51 to 1.78) and 1.71 (95% confidence interval, 0.98 to 2.99) within the hydrophobic versus the standard-polyurethane group and within the chlorhexidine versus the standard-polyurethane group, respectively. Problems from any trigger through the interval of PICC placement occurred in 21.5, 38.6, and 21.7% within the hydrophobic, chlorhexidine, and standard-polyurethane teams, respectively.
“The current findings reflect the complexity in preventing multifactorial PICC dysfunction, with no apparent difference in the incidence of device failure or of catheter-acquired bloodstream infection according to PICC type,” the authors write.
Extra info:
Amanda J. Ullman et al, A Comparability of Peripherally Inserted Central Catheter Supplies, New England Journal of Drugs (2025). DOI: 10.1056/NEJMoa2406815
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Danger of system failure related with completely different peripherally inserted central catheter supplies (2025, January 9)
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