Decrease physique mass index (BMI) and waist circumference and better high-density lipoprotein are seen within the decade previous prognosis of dementia, in accordance with a examine printed on-line Feb. 7 in JAMA Community Open.
Zimu Wu, Ph.D., from Monash College in Melbourne, Australia, and colleagues carried out a case-control examine involving a pattern drawn from community-dwelling members within the Aspirin in Lowering Occasions within the Aged examine. Dementia instances have been matched to dementia-free controls for sociodemographic traits and time of prognosis.
The analyses included 1,078 dementia instances and 4,312 controls. The researchers discovered that in contrast with controls, dementia instances had decrease BMI for all years from −7 to 0 years and had decrease waist circumference for all years from −10 to 0 years. In contrast with controls, instances additionally had a quicker decline in BMI and waist circumference.
Instances typically had increased high-density lipoprotein levels of cholesterol, particularly from 5 to 3 years earlier than dementia, with a decline in ranges simply earlier than prognosis. Decrease systolic blood stress and triglycerides have been seen in dementia instances within the decade earlier than prognosis, whereas increased low-density lipoprotein and whole levels of cholesterol have been seen; these ranges weren’t considerably completely different from these of controls.
“These findings indicate that certain cardiometabolic factors may deviate from their usual levels before dementia,” the authors write. “These differences may be risk factors or early indicators associated with cognitive impairment, suggesting the importance of dynamic monitoring.”
Two authors disclosed ties to the pharmaceutical business.
Extra data:
Zimu Wu et al, Cardiometabolic Trajectories Previous Dementia in Neighborhood-Dwelling Older People, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2024.58591
© 2025 HealthDay. All rights reserved.
Quotation:
Decline in BMI, waist circumference seen in decade earlier than dementia (2025, February 7)
retrieved 8 February 2025
from https://medicalxpress.com/information/2025-02-decline-bmi-waist-circumference-decade.html
This doc is topic to copyright. Aside from any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.
