Deprescribing antihypertensive remedy isn’t related to the danger for hospitalization for myocardial infarction (MI) or stroke in long-term care residents, in accordance with a examine revealed on-line Nov. 25 in JAMA Community Open.
Michelle C. Odden, Ph.D., from Stanford College in California, and colleagues in contrast the incidence of hospitalization for MI or stroke amongst long-term care residents who’re deprescribed or proceed antihypertensive remedy. The evaluation included 13,096 U.S. veterans residing in long-term care (Oct. 1, 2006, to Sept. 30, 2019) taking a minimum of one antihypertensive remedy.
The researchers discovered that 17.8 p.c of veterans have been deprescribed antihypertensive remedy throughout a interval of 12 weeks. Over two years, an identical estimated unadjusted cumulative incidence of stroke or MI hospitalization was seen for residents who have been and weren’t deprescribed antihypertensives (11.2 versus 8.8 p.c). In absolutely adjusted fashions, the per-protocol evaluation outcomes confirmed no affiliation of antihypertensive deprescribing with MI or stroke hospitalization (hazard ratio, 0.93; 95 p.c confidence interval, 0.70 to 1.26).
“A randomized clinical trial would help address concerns about unmeasured confounding but could be challenging to implement in this complex population,” the authors write. “More research is needed on deprescribing methods and potential consequences to inform this growing practice and inform patient and clinician shared decision-making.”
Extra data:
Michelle C. Odden et al, Antihypertensive Deprescribing and Cardiovascular Occasions Amongst Lengthy-Time period Care Residents, JAMA Community Open (2024). DOI: 10.1001/jamanetworkopen.2024.46851
Julie C. Lauffenburger, Shifting Deprescribing Past Doubtlessly Dangerous Drugs, JAMA Community Open (2024). DOI: 10.1001/jamanetworkopen.2024.46857
Quotation:
Deprescribing antihypertensives not tied to hospitalization for coronary heart assault, stroke (2024, December 3)
retrieved 3 December 2024
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