Genetic options of ctDNA in lymphoma. Credit score: Journal of Hematology & Oncology (2025). DOI: 10.1186/s13045-025-01673-7
A analysis workforce led by Prof. Gu Hongcang from the Hefei Institutes of Bodily Science of the Chinese language Academy of Sciences has revealed a complete systematic evaluate on circulating tumor DNA (ctDNA) applied sciences and their purposes in lymphoma.
The examine, revealed within the Journal of Hematology & Oncology, presents a radical evaluation of current developments in ctDNA detection strategies and their scientific significance.
Lymphoma, a fancy malignancy originating in lymphocytes and lymphoid tissues, poses important challenges for each analysis and therapy as a result of its numerous pathological subtypes. Conventional tissue biopsies, whereas invaluable, are invasive and infrequently fail to seize the total heterogeneity of the illness.
In distinction, liquid biopsy—particularly ctDNA evaluation—has gained consideration as a noninvasive different to detect tumor-specific genetic and epigenetic alterations, offering a promising instrument for extra correct analysis and monitoring.
On this evaluate, the researchers highlighted the potential of ctDNA profiling in lymphoma administration, together with analysis, therapy response analysis, and danger stratification. By analyzing DNA fragments shed by tumor cells into the bloodstream, ctDNA serves as a vital biomarker for mutation detection, monitoring clonal evolution, and assessing therapeutic effectiveness.
Overview of lymphoma sorts, subtypes, genetic adjustments, and impacted signaling pathways on this evaluate. Credit score: Journal of Hematology & Oncology (2025). DOI: 10.1186/s13045-025-01673-7
They offered sturdy proof supporting the combination of ctDNA testing into routine scientific observe, which may improve personalised therapy methods and enhance affected person outcomes.
The researchers additionally explored varied ctDNA detection applied sciences, comparable to PCR-based strategies and next-generation sequencing (NGS), each of which provide excessive sensitivity and specificity for noninvasive illness monitoring.
Whereas a lot of the main target has been on diffuse giant B-cell lymphoma (DLBCL), ctDNA evaluation reveals promise for different lymphoma subtypes, together with follicular lymphoma, marginal zone lymphoma, and central nervous system lymphoma.
With ongoing developments in ctDNA applied sciences, the strategy is poised to turn out to be a normal scientific instrument, providing new potentialities for higher survival charges and high quality of life for lymphoma sufferers.
Extra info:
Lina Fu et al, Circulating tumor DNA in lymphoma: applied sciences and purposes, Journal of Hematology & Oncology (2025). DOI: 10.1186/s13045-025-01673-7
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Developments in ctDNA detection promise improved lymphoma outcomes (2025, April 1)
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