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An Amsterdam UMC-led research has discovered that migrants, on this case from West Africa to Europe, expertise a “clear change” of their microbiome composition in comparison with their non-migrant friends in West Africa, which exposes them to a rise in heart problems.
These peer-reviewed findings are printed within the journal Intestine Microbes, demonstrating that contributors who misplaced particular teams of microbes or acquired particular new teams of microbes had larger charges of cardiovascular danger components resembling hypertension, diabetes, weight problems, and poor kidney operate.
“The results clearly demonstrate the importance of our findings in relation to migration-related health outcomes,” explains postdoctoral researcher at Amsterdam UMC and first creator of the research, Barbara Verhaar, who carried out the analysis along with colleagues on the College of Ghana, and Kwame Nkrumah College of Science & Expertise (KNUST).
“It was already thought that migration had an effect on an individual’s microbiome, but previous studies have either lacked in the number of individuals included, didn’t control for variations in diet or only compared first- and second-generation migrants. Our study makes use of our own RODAM study cohort to definitively demonstrate this change,” says Verhaar.
The Amsterdam UMC-led research included greater than 1,100 people from two separate continents and three areas: rural Ghana, city Ghana and the Netherlands. Respondents accomplished equivalent dietary questionnaires and offered each fecal and blood samples to find out the composition of their intestine microbiomes.
Analyses revealed the presence of various microbes throughout the three teams, in step with the speculation that migration would have an effect on microbiome composition. The findings present that some teams of microbes disappear, and new ones emerge alongside the migration axis.
Earlier research, in addition to the World Well being Group, be aware that migrants incessantly expertise poorer well being outcomes than native residents, and analysis from Amsterdam UMC has discovered this additionally to be the case within the Netherlands.
“This research underscores the relevance of gut health and how we look at the adverse health outcomes that are often associated with migration,” provides Charles Agyemang, Professor of International Migration, Ethnicity & Well being at Amsterdam UMC and senior creator of the research.
“It’s fascinating to study that once we migrate, we lose some related microbes we acquired in our dwelling international locations and decide up new microbes within the new international locations, and this may affect our well being very importantly.
“We found that macronutrient groups such as protein, fat and salt in food were strongest associated with gut microbiota composition and these were higher in migrants, which might have contributed to the shift in gut microbiota composition. Future longitudinal studies are needed to verify these findings.”
Cardiometabolic danger is a rising concern for researchers throughout the globe and Agyemang is at the moment main a bunch of tasks, each within the Netherlands and a number of other African international locations, that goal to develop higher interventions to decrease the danger of creating cardiometabolic ailments, resembling diabetes and hypertension; and to enhance administration of cardiometabolic ailments.
As a part of these efforts, as on this research, he works with a number of establishments throughout the globe, particularly within the African area, to make sure that analysis in Amsterdam is strengthened with worldwide knowledge and, additionally, that analysis findings are translated into concrete coverage.
“The findings of this study provide important insights into how migration can reshape our gut microbiota and subsequent health outcomes and emphasize the need for north-south collaborations,” provides Ellis Owusu-Dabo, Professor of Epidemiology and International Well being, KNUST.
Extra data:
Intestine microbiota shift in Ghanaian people alongside the migration axis: the RODAM-Execs cohort, Intestine Microbes (2025). DOI: 10.1080/19490976.2025.2471960
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Amsterdam College Medical Facilities
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Dietary modifications post-migration alter intestine microbiome to extend coronary heart illness danger, research finds (2025, April 7)
retrieved 7 April 2025
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