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A examine on donor lungs preserved outdoors the physique earlier than transplantation demonstrated that the hypothermic oxygenated machine perfusion (HOPE) approach is a secure and efficient lung preservation methodology, even with whole out-of-body instances approaching 20 hours.
Jitte Jennekens, MSc, organ perfusionist/transplant coordinator on the UMC Utrecht within the Netherlands, introduced the examine outcomes at right this moment’s Annual Assembly and Scientific Classes of the Worldwide Society of Coronary heart and Lung Transplantation (ISHLT) in Boston.
“This technique is being used to preserve donor livers and kidneys and is being studied in clinical trials for hearts, but it hasn’t gotten that much attention for lung preservation yet,” stated Jennekens.
Ex vivo lung perfusion (EVLP) is a method that permits for donor lungs to be maintained, assessed, and probably reconditioned outdoors of the physique earlier than transplantation. The lungs are related to a pump and a ventilator and perfused with an answer that capabilities as a physiological fluid.
The UMC Utrecht developed its HOPE protocol to securely prolong perfusion instances, to take care of the viability of the lungs in a single day till the transplantation may be carried out through the day.
The HOPE protocol eliminates the second interval on ice by assessing the lungs throughout one hour of nEVLP after which preserving the lungs at 12 levels C till the process.
Jennekens introduced information evaluating the outcomes of 12 circumstances carried out utilizing the nEVLP-HOPE protocol with a historic cohort of donor lungs transplanted immediately into sufferers with out ex vivo lung perfusion.
The management cohort included 118 circumstances of lungs transplanted immediately with out perfusion between 2017 and 2022. The circumstances have been carried out between 2022 and 2024 utilizing the HOPE protocol for logistical causes.
No lungs within the nEVLP-HOPE group have been rejected for transplantation, and short-term outcomes have been comparable between the examine and management teams.
“Our findings indicate that HOPE is a safe and effective lung preservation method after a period of normothermic EVLP,” Jennekens stated.
Jennekens stated the following step is to find out the preservation technique that will likely be most helpful to a particular sort of donor lung.
“Extending perfusion times for donor lungs outside of the body will allow for a future in which donor lungs can be optimized with different therapies,” she stated.
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Donor lungs safely preserved as much as 20 hours out-of-body previous to transplantation (2025, April 27)
retrieved 27 April 2025
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