For sufferers with hepatitis B virus, alcohol is related to dose-dependent elevated dangers for cirrhosis and hepatocellular carcinoma (HCC), in accordance with a assessment printed on-line Jan. 21 within the Journal of Scientific and Translational Hepatology.
Yin-Ping Wu, from the Qilu College Hospital of Shandong College in Jinan, China, and colleagues pooled knowledge on the incidence of cirrhosis and HCC and developed a dose-dependent mannequin of the impact of alcohol on cirrhosis and HCC. Information was included for 33,272 sufferers with hepatitis B virus from 45 research.
The researchers discovered that the general pooled odds ratios have been 2.27 and a pair of.61 for cirrhosis and HCC, respectively, amongst drinkers versus nondrinkers. In contrast with low-level drinkers, high-level drinkers had estimated pooled odds ratios of two.34 and a pair of.42 for cirrhosis and HCC, respectively. A linear dose-dependent evaluation confirmed that every every day consumption of 12 g of alcohol elevated the dangers for cirrhosis and HCC by 6.2 and 11.5%, respectively.
“Our meta-analysis is the first report to show that alcohol consumption increases the risk of cirrhosis and HCC in patients with HBV infection in a dose-dependent manner,” the authors write.
Extra info:
Yin-Ping Wu et al, Dose-dependent Relationship between Alcohol Consumption and the Dangers of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Evaluation, Journal of Scientific and Translational Hepatology (2024). DOI: 10.14218/JCTH.2024.00379
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Dose-dependent hyperlink seen for alcohol, cirrhosis, liver most cancers in sufferers with hepatitis B (2025, January 29)
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