Endoscopic full-thickness plication (EFTP), which improves the valvular mechanism of the gastroesophageal junction, is efficacious for managing gastroesophageal reflux illness (GERD) signs, in response to analysis revealed within the November challenge of JGH Open.
Muhammad Shahzil, M.D., from Weiss Memorial Hospital in Chicago, and colleagues performed a meta-analysis to check EFTP to a sham process for therapy of refractory GERD. Three randomized managed trials with 272 sufferers had been included: 136 of the sufferers underwent EFTP and 136 had sham procedures.
The researchers noticed a major discount in proton pump inhibitor utilization (danger ratio, 0.51) and a major enchancment in GERD-health-related high quality of life scores at three months (danger ratio, 15.81). There was no vital distinction within the DeMeester scores. No vital distinction was seen in time with esophageal pH
“Our findings contribute to the evidence base, but further research comparing EFTP to other minimally invasive techniques is crucial for obtaining comprehensive evidence,” the authors write. “Such research will continue to inform clinical decisions and help clinicians decide the most suitable treatment options tailored to individual patients.”
Extra data:
Muhammad Shahzil et al, Endoscopic Full‐Thickness Plication for the Remedy of Gastroesophageal Reflux Illness: A Systematic Overview and Meta‐Evaluation of Randomized Sham Managed Trials, JGH Open (2024). DOI: 10.1002/jgh3.70056
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