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A paper printed within the Journal of Medical Oncology, titled “Comparative Analysis of Intracranial Response Assessment Criteria in Patients With Melanoma Brain Metastases Treated With Combination Nivolumab + Ipilimumab in CheckMate 204,” examines how completely different imaging standards can be utilized to evaluate mind tumor responses in sufferers with melanoma handled with immunotherapy medicine.
The researchers recognized one imaging methodology that was extra correct in predicting survival in comparison with others. Whereas additional work is required, they are saying the examine is promising and highlights the significance of extra constant imaging requirements in medical trials.
For the examine, the researchers checked out completely different measurements of mind metastases on MRI scans taken over the course of two years or longer for sufferers in a multi-center Section II medical trial evaluating an immunotherapy for mind most cancers.
They took into consideration the affected person’s response to the remedy, together with progression-free survival (PFS) and general survival (OS), to find out which set of standards was most predictive of affected person consequence.
They discovered {that a} modified imaging strategy (mRECIST) and volumetric measurements (3D measurement evaluation) had been extra correct in predicting survival in comparison with different strategies. These approaches labored effectively even for small tumors, suggesting they need to be included in future research when evaluating remedy response.
Total, these findings intention to enhance how oncologists consider and deal with mind metastases in most cancers sufferers.
The researchers are growing automated segmentation know-how to enhance the consistency of 3D tumor measurements, with the objective of creating a normal instrument for evaluating mind metastases.
Extra info:
Huang R et al, Comparative Evaluation of Intracranial Response Evaluation Standards in Sufferers With Melanoma Mind Metastases Handled With Mixture Nivolumab + Ipilimumab in CheckMate 204, Journal of Medical Oncology (2025). DOI: 10.1200/JCO.24.00953. ascopubs.org/doi/10.1200/JCO.24.00953
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Enhancing predictions about mind most cancers outcomes with the best imaging standards (2025, January 3)
retrieved 3 January 2025
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