Mannequin of differentiated thyroid most cancers (DTC) metastatic development. Credit score: Thyroid® (2025). DOI: 10.1089/thy.2024.0303
Researchers from the Endocrine Tumors group on the Germans Trias i Pujol Analysis Institute (IGTP), in collaboration with 5 college hospitals, have performed the primary complete research of DNA methylation patterns in metastatic differentiated thyroid most cancers (DTC).
Printed within the journal Thyroid, the research identifies an epigenetic signature comprising 156 CpG websites in main tumors that might assist stratify sufferers in keeping with their threat of creating distant metastases.
The research supplies new insights into the function of DNA methylation—a key epigenetic mechanism in gene expression regulation—in thyroid most cancers development. These findings contribute to a greater understanding of the illness and open new avenues for affected person stratification and customized therapy methods.
A multicenter evaluation of DNA methylation
The researchers analyzed samples from regular thyroid tissue, low-risk main tumors, main tumors from sufferers who later developed metastases, lymph node metastases, and distant metastases. The outcomes present a progressive enhance in DNA methylation alterations throughout tumor development, predominantly characterised by international hypomethylation, supporting a linear mannequin of metastasis.
The research additionally highlights variations in DNA methylation dynamics between the principle histological subtypes of thyroid most cancers. Whereas papillary (PTC) and follicular (FTC) carcinomas exhibit distinct methylation profiles within the early levels, each converge in direction of frequent epigenetic patterns throughout metastatic development. These findings recommend shared epigenetic mechanisms in superior levels of the illness, whatever the preliminary tumor subtype.
A instrument for metastasis prediction
The detailed evaluation enabled the identification of a particular signature of 156 altered CpG websites in main tumors from sufferers with distant metastases, validated in an impartial cohort. This signature represents a promising prognostic instrument for the early identification of high-risk sufferers at analysis, enhancing threat stratification and supporting the adoption of customized medical administration methods for thyroid most cancers.
“This study confirms that changes in DNA methylation play a key role in the progression of thyroid cancer and bring us closer to the early identification of high-risk patients. The collaboration between five university hospitals and the IGTP has been essential to ensure the robustness of the results and highlights the importance of multidisciplinary research in advancing precision medicine for less-studied tumors such as thyroid cancer,” says Mireia Jordà, principal investigator of the research and chief of the Endocrine Tumors Group at IGTP.
This analysis lays the groundwork for enhancing prognostic instruments in thyroid most cancers and reinforces the worth of incorporating epigenetic evaluation into customized care methods for sufferers with this illness.
Extra data:
Helena Rodríguez-Lloveras et al, DNA Methylation Dynamics and Prognostic Implications in Metastatic Differentiated Thyroid Most cancers, Thyroid (2025). DOI: 10.1089/thy.2024.0303
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Germans Trias i Pujol Analysis Institute
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Epigenetic signature helps predict threat of metastatic thyroid most cancers development (2025, April 25)
retrieved 25 April 2025
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