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A examine led by the College of California, Irvine has discovered cardiovascular circumstances similar to hypertension and diabetes, that are identified to contribute to mind blood vessel injury in youthful populations, to not be related to an elevated threat of such hurt in people 90 and older.
The work, printed within the journal Alzheimer’s & Dementia, means that the connection amongst blood stress, vascular well being and mind growing old is extra advanced than beforehand thought.
“For decades, we’ve known that factors like high blood pressure and diabetes can injure blood vessels in the brain, increasing the risk for cognitive decline and dementia. However, our research found that these patterns may change as people age,” stated corresponding writer Dr. Ravi Rajmohan, UC Irvine medical teacher of neurology. “Even more intriguing, the use of blood pressure-lowering medication in this 90-plus group was linked to a lower likelihood of specific types of brain damage.”
Workforce members analyzed the connection between cardiovascular-related modifications within the mind and self-reported vascular threat elements or use of heart-related drugs by analyzing information from 267 individuals within the Nationwide Institute on Ageing’s 90+ Examine, one of many largest and most complete analysis initiatives on the oldest-old inhabitants. They utilized statistical fashions that accounted for age, intercourse and schooling and located that the presence of mind modifications was not linked to conventional threat elements like hypertension or diabetes.
As well as, they found that sure drugs confirmed potential proactive results. Diuretics have been linked to a decrease probability of atherosclerosis, generally referred to as “hardening of the arteries,” and beta blockers and vasodilators have been related to lowered odds of cerebral amyloid angiopathy, the buildup of a sort of protein in mind blood vessels.
“Our findings challenge the idea that traditional vascular risk factors are always harmful to brain health in the 90-plus population,” Rajmohan stated. “Our findings could replicate the effectiveness of remedy for these circumstances, or they might be influenced by survival bias, as people with untreated or extreme threat elements could not dwell into their 90s.
“Further research is needed to explore whether blood pressure-lowering medications could directly reduce the risk of brain blood vessel damage and dementia under specific circumstances. Such knowledge could lead to more personalized advice for managing blood pressure and improving brain health outcomes.”
Extra info:
Ravi Rajmohan et al, Vascular threat elements and cerebrovascular pathologic modifications on post-mortem: The 90+ Examine, Alzheimer’s & Dementia (2025). DOI: 10.1002/alz.14454
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Examine challenges conventional threat elements for mind well being in these over 90 (2025, January 7)
retrieved 7 January 2025
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