For ladies with moderate-to-severe vasomotor signs related to endocrine remedy for hormone receptor (HR)-positive breast most cancers, elinzanetant, a neurokinin-targeted remedy, reduces the frequency of vasomotor signs, in response to a research revealed on-line June 2 within the New England Journal of Medication to coincide with the annual assembly of the American Society of Medical Oncology, held from Could 31 to June 4 in Chicago.
Fatima Cardoso, M.D., from the Champalimaud Basis in Lisbon, Portugal, and colleagues carried out a part 3 trial involving girls aged 18 to 70 years with moderate-to-severe vasomotor signs related to endocrine remedy for HR-positive breast most cancers or its prevention.
Ladies had been randomly assigned to obtain once-daily elinzanetant at a dose of 120 mg for 52 weeks or once-daily placebo for 12 weeks adopted by once-daily elinzanetant at a dose of 120 mg for 40 weeks (316 and 158 sufferers, respectively). Solely one of many sufferers was taking endocrine remedy for breast most cancers prevention.
The researchers discovered that the imply change from baseline within the imply day by day frequency of moderate-to-severe vasomotor signs at week 4 was −6.5 and −3.0 episodes for these receiving elinzanetant and placebo, respectively (least-squares imply distinction, −3.5 episodes). The imply change was −7.8 and −4.2 episodes amongst these receiving elinzanetant and placebo, respectively, at week 12 (least-squares imply distinction, −3.4 episodes).
Total, 69.8% and 62.0% of these receiving elinzanetant and placebo, respectively, reported not less than one opposed occasion throughout weeks 1 via 12; critical opposed occasions occurred in 2.5% and 0.6%, respectively.
“In a finding consistent with the results of previous trials involving postmenopausal women, treatment with elinzanetant resulted in significant decreases in the frequency of vasomotor symptoms and in sleep disturbances and improvements in health-related quality of life among women with moderate-to-severe vasomotor symptoms taking endocrine therapy for breast cancer,” the authors write.
A number of authors disclosed ties to Bayer, which is growing elinzanetant and funded the research.
Extra data:
Fatima Cardoso et al, Elinzanetant for Vasomotor Signs from Endocrine Remedy for Breast Most cancers, New England Journal of Medication (2025). DOI: 10.1056/NEJMoa2415566
Ann H. Partridge, Menopausal Symptom Administration in Breast Most cancers Survivors—A Promising New Possibility, New England Journal of Medication (2025). DOI: 10.1056/NEJMe2506475
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