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Researchers from the HIV Prevention Trials Community (HPTN) have introduced outcomes from the HPTN 094 (“INTEGRA”) examine on the 2025 Convention on Retroviruses and Opportunistic Infections (CROI) in San Francisco.
The primary findings from this randomized managed trial that enrolled individuals who inject medication confirmed that comparable numbers of individuals have been on medicine for opioid use dysfunction (MOUD) and antiretroviral remedy (ART) for HIV care or prevention at 26 weeks post-randomization both to an intervention arm that offered built-in providers with peer navigation in a cellular unit or to an energetic management arm that obtained navigation to built-in providers at accessible group businesses solely.
Findings confirmed that about 7% of individuals in each arms have been decided as alive and on MOUD, about 35% of individuals residing with HIV have been virally suppressed, and between 3 and 5% on HIV pre-exposure prophylaxis (PrEP) at 26 weeks post-randomization.
“With 90 percent retention of participants, most of whom had unstable housing through the trial, HPTN 094 provided foundational evidence that mobile units and peer navigation are acceptable in confronting structural and systemic barriers that hinder access to care for addiction and HIV, as well as prevention of HIV,” stated Dr. Steven Shoptaw, HPTN 094 protocol co-chair and professor within the College of California at Los Angeles (UCLA) departments of Household Medication, Psychiatry, and Biobehavioral Sciences.
“HPTN 094 also provides data on establishing an integrated care model for improving health outcomes among high-risk populations.”
HPTN 094 is the one randomized managed trial to check the efficacy of utilizing cellular built-in well being providers for opioid use dysfunction and HIV prevention or therapy for individuals who inject medication. Main outcomes have been being alive at 26 weeks post-randomization, utilizing MOUD, and ART for HIV prevention or care amongst individuals who inject medication within the U.S.
By design, this examine examined outcomes when delivering whole-person, built-in methods utilizing cellular medical items with peer navigation to native providers in comparison with peer navigation to native providers alone.
“Opioid use is a critical factor in the lives of people who inject drugs, hindering access to essential health services,” stated Dr. Wafaa El-Sadr, HPTN co-principal investigator, director of ICAP, and professor of epidemiology and medication at Columbia College in New York. “HPTN 094 met people living with opioid use disorder where they are by designing an intervention that brought integrated and judgment-free health, supported by peer navigation.”
The randomized examine of 447 individuals was performed in Houston, Los Angeles, New York, Philadelphia, and Washington, D.C. Eligible individuals have been randomized to both an intervention or energetic management arm. Intervention arm individuals obtained “one-stop” well being providers in a cellular well being unit and peer navigation from a peer restoration coach for 26 weeks.
Throughout this time, the cellular unit offered individuals with major care providers, together with MOUD, ART, PrEP, sexually transmitted an infection and hurt discount providers, in addition to screening and referral for hepatitis, psychological well being points, and different medical situations. After 26 weeks, individuals within the intervention arm have been referred to well being providers accessible locally. Lively management arm individuals obtained peer navigation to comparable well being providers accessible locally all through the trial.
“Although not statistically significant, a key finding of the study was that the study group who received care through mobile medical units plus peer navigation had 70 percent lower odds for all-cause mortality (three deaths out of 224 participants) compared to the control arm receiving peer navigation to local services alone (10 deaths out of 223 participants),” stated Dr. Myron Cohen, HPTN co-principal investigator, and director of the Institute for International Well being on the College of North Carolina in Chapel Hill.
“More research is needed to confirm the study results and examine the long-term effects of mobile health care units, including their cost-effectiveness and ability to improve health outcomes.”
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HIV Prevention Trials Community (HPTN)
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Examine examines a novel option to carry habit care and HIV prevention to individuals who inject medication (2025, March 12)
retrieved 13 March 2025
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