The rise in hyaluronan synthesis is mediated by the induction of HAS3 expression, triggered by the activation of the JNK–c-Jun pathway as a result of cadmium publicity. Credit score: Dr. Chika Yamamoto
A analysis workforce has revealed that cadmium, a poisonous heavy metallic, will increase the synthesis of hyaluronan in vascular endothelial cells. Their examine has additionally recognized that this course of is mediated by the induction of hyaluronan synthase 3 (HAS3) expression.
In Japan, cadmium is effectively referred to as the causative agent of Itai-itai illness, and quite a few epidemiological research have highlighted its position as a danger issue for atherosclerosis. This examine gives new insights into the poisonous mechanisms of cadmium, demonstrating that it accelerates the development of atherosclerosis by growing hyaluronan synthesis.
This analysis is printed on-line within the journal Toxicology. The workforce was led by Ms. Misaki Shirai (JSPS Analysis Fellow), Dr. Takato Hara, and Dr. Chika Yamamoto from the Division of Environmental Well being Science, College of Pharmaceutical Sciences, Toho College.
Key factors embrace:
Cadmium will increase hyaluronan synthesis in vascular endothelial cells.
The rise in hyaluronan synthesis is mediated by the induction of HAS3 expression, triggered by the activation of the JNK–c-Jun pathway as a result of cadmium publicity.
Disruption of HAS3 expression steadiness in vascular endothelial cells as a result of cadmium publicity could speed up the development of inflammatory vascular illnesses, together with atherosclerosis.
Extra info:
Misaki Shirai et al, Cadmium promotes hyaluronan synthesis by inducing hyaluronan synthase 3 expression in cultured vascular endothelial cells through the c-Jun N-terminal kinase–c-Jun pathway, Toxicology (2025). DOI: 10.1016/j.tox.2025.154062
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Examine reveals how poisonous metallic damages blood vessels (2025, February 12)
retrieved 12 February 2025
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