Overview of HLA information assets and their purposes in HLA gene evolution. Credit score: Xu Tao and He Shunmin’s group
A brand new research led by Profs. Xu Tao and He Shunmin from the Institute of Biophysics of the Chinese language Academy of Sciences has revealed how human leukocyte antigen (HLA) genes, central to the immune system, affect each pathogen resistance and susceptibility to autoimmune ailments.
Specializing in the Han Chinese language inhabitants, the research affords new proof for the co-evolution of people and pathogens. The findings have been printed in Genomics, Proteomics & Bioinformatics.
This research, centered on the “NyuWa” genome useful resource, utilized superior HLA genotyping instruments to carry out high-resolution (as much as 6-digit) genotyping of 31 HLA genes in 8,278 people worldwide. It achieved an accuracy of 94% to 97% on the amino acid sequence degree.
The ensuing information set, now publicly out there, represents some of the complete assets on world HLA gene range, with a selected emphasis on Han Chinese language.
Primarily based on this useful resource, the researchers systematically explored the genetic correlations between pathogen-adapted HLA genes and autoimmune illness susceptibility within the Han Chinese language inhabitants, providing an evolutionary medication perspective on illness origins and development.
By analyzing the genetic associations between pathogen-adapted HLA genes and people linked to autoimmune ailments, the research revealed that many HLA alleles concerned in pathogen adaptation additionally enhance the chance of autoimmune ailments.
These findings underscore a key idea in evolutionary medication—the concept that traits developed to defend in opposition to pathogens could inadvertently heighten the chance of immune system dysregulation in trendy environments.
This research not solely supplies a novel method for understanding the origins of illness and human evolution, but in addition affords essential assist for enhancing medical practices and addressing trendy well being challenges.
Extra data:
Shuai Liu et al, The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Illnesses within the Han Chinese language, Genomics, Proteomics & Bioinformatics (2025). DOI: 10.1093/gpbjnl/qzaf038
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Chinese language Academy of Sciences
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Examine uncovers hyperlink between pathogen adaptation and autoimmune ailments in Han Chinese language (2025, Might 21)
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