Credit score: Pixabay/CC0 Public Area
Gene mutations attributable to publicity to sure chemical compounds have been linked to the event of gliomas, the commonest kind of malignant mind tumor. New analysis reveals that amongst sufferers with gliomas, these mutations are extra frequent in firefighters than in people with different occupations. The findings are revealed on-line in Most cancers.
The gene mutations of curiosity on this examine make up a mutational sample or “signature” that different investigators beforehand related to publicity to haloalkanes, that are utilized in flame retardants, hearth extinguishants, refrigerants, and different merchandise.
“As firefighters have exposure to such chemical agents, we examined mutational signatures in glioma brain tumors diagnosed in persons who worked as firefighters versus those who did not,” stated senior writer Elizabeth B. Claus, MD, Ph.D., a professor on the Yale College Faculty of Public Well being and attending neurosurgeon at Mass Normal Brigham.
Amongst 35 contributors within the College of California Grownup Glioma Examine, 17 had an occupational historical past of firefighting. In contrast with the opposite 18 contributors, firefighters had been extra more likely to have the haloalkane-associated mutational signature, particularly if that they had been firefighters for a few years.
Amongst non-firefighters, the mutational signature was extra probably in these with occupations that additionally presumably uncovered them to haloalkanes, reminiscent of automotive portray and machine upkeep.
“Our study provides preliminary data but will need confirmation in a larger data set and across a wider range of occupations,” stated Dr. Claus. “Identifying exposure to such mutational agents is important to inform public health intervention strategies and pinpoint occupational hazards that may be avoidable.”
Extra info:
Vincent L. Cannataro, et al. Glioma mutational signatures related to haloalkane publicity are enriched in firefighters, Most cancers (2025). DOI: 10.1002/cncr.35732
Quotation:
Firefighters face a better mind most cancers danger related to gene mutations attributable to chemical publicity, examine suggests (2025, March 10)
retrieved 10 March 2025
from https://medicalxpress.com/information/2025-03-firefighters-higher-brain-cancer-gene.html
This doc is topic to copyright. Other than any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for info functions solely.
