A tailor-made strategy of vitamin D3 supplementation in sufferers who’ve suffered a coronary heart assault considerably reduces their threat of a second coronary heart assault, a brand new examine from coronary heart researchers at Intermountain Well being in Salt Lake Metropolis finds. Credit score: Intermountain Well being
A tailor-made strategy of vitamin D3 supplementation in sufferers who’ve suffered a coronary heart assault considerably reduces their threat of a second coronary heart assault, a brand new examine from coronary heart researchers at Intermountain Well being in Salt Lake Metropolis finds.
In a big, randomized scientific trial, Intermountain Well being researchers discovered that treating coronary heart assault sufferers in a “target to treat” vogue, the place sufferers’ blood ranges of vitamin D have been monitored and vitamin D3 dosing adjusted to realize optimum ranges, lower their threat of a second coronary heart assault in half.
Outcomes of the examine have been offered on Nov. 9 on the 2025 American Coronary heart Affiliation Scientific Classes in New Orleans.
The outcomes are promising, stated Heidi Might, Ph.D., cardiovascular epidemiologist at Intermountain Well being and principal investigator of the examine.
“We observed no adverse outcomes when giving patients higher doses of vitamin D3 supplementation, and to significantly reduce the risk of another heart attack, which are exciting results,” stated Dr. Might. “We’re excited with these results but know we have further work to do to validate these findings.”
The findings are necessary as between a half to two-thirds of individuals worldwide have low ranges of vitamin D.
Previously, most individuals have been in a position to get sufficient vitamin D from the solar. Nonetheless, with adjustments in way of life and proposals to cut back pores and skin most cancers threat, solar publicity has decreased, and people should get hold of sufficient vitamin D from various sources, akin to supplementation with vitamin D3.
Many observational research have proven low ranges of vitamin D to be related to poor cardiovascular outcomes. Nonetheless, earlier scientific trials offered customary supplementation doses to sufferers with no discount in cardiovascular threat discovered. Intermountain coronary heart researchers questioned if it was extra necessary to extend a affected person’s vitamin D degree to a sure degree somewhat than simply present supplementation.
“Previous studies just gave patients supplementation without regularly checking blood levels of vitamin D to determine what supplementation achieved,” stated Dr. Might.
“With more targeted treatment, when we checked exactly how supplementation was working and made adjustments, we found that patients had their risk of another heart attack cut in half.”
The Intermountain examine, known as the TARGET-D trial, enrolled sufferers from April 2017 to Might 2023 and included 630 Intermountain Well being sufferers who had a coronary heart assault inside a month of their enrollment. Members have been adopted till March 2025 for the incidence of cardiovascular occasions.
Researchers randomized examine sufferers into two teams: those that acquired no administration of vitamin D3 by the examine and those that acquired focused vitamin D3 therapy.
Within the vitamin D therapy group, the aim was to lift their blood ranges of vitamin D to greater than 40 nanograms per ml (ng/mL). Of the center assault sufferers enrolled within the examine, 85% had inadequate vitamin D3 ranges (
Of those that acquired focused therapy, greater than 50% required an preliminary vitamin D3 dose of 5,000 worldwide items (IU), the place present supplementation solutions are often between 600 to 800 IU.
For sufferers within the examine who acquired focused therapy, their vitamin D blood ranges have been checked annually to find out in the event that they have been above 40 ng/mL. For sufferers whose vitamin D ranges have been decrease, they have been examined each three months with their dosage adjusted, then yearly after they achieved 40 ng/mL.
Intermountain researchers then adopted sufferers to see who had follow-up main cardiac occasions (MACE), together with coronary heart assault, coronary heart failure hospitalization, stroke or loss of life.
Of the 630 sufferers enrolled within the scientific trial, 107 skilled a significant cardiac occasion.
Researchers discovered no vital distinction within the threat of MACE between the teams. Nonetheless, they did discover that the chance of a follow-up coronary heart assault was decreased by half in these sufferers who acquired focused vitamin D administration.
The following step for researchers is to do a bigger scientific trial to reaffirm these findings.
A bigger examine group will permit researchers to adequately consider whether or not focused vitamin D administration reduces the chance of growing or decreasing the chance of different heart problems, stated Dr. Might.
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Intermountain Healthcare
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Focused vitamin D3 supplementation cuts threat of second coronary heart assault in half, examine finds (2025, November 9)
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