Sufferers with preexisting gastroesophageal reflux illness (GERD) have an elevated threat for incident acute myocardial infarction (AMI), in keeping with a research printed on-line Oct. 13 in JGH Open.
Tinsae Anebo, M.D., from Jefferson Einstein Hospital in Philadelphia, and colleagues carried out a scientific evaluate and meta-analysis to look at whether or not GERD is a threat issue for AMI. The meta-analysis included 1,324,362 individuals from six research.
The researchers discovered that in contrast with these with out GERD, sufferers with GERD had a 27% elevated threat for incident AMI (pooled relative threat, 1.27). No vital publication bias was seen within the funnel plot. Power irritation, oxidative stress, and autonomic dysfunction have been potential mechanisms underlying this affiliation.
“Our study revealed that GERD is associated with a higher incidence of AMI. Further research is needed to understand the underlying mechanisms, evaluate preventive strategies, and develop targeted interventions to mitigate this risk and improve patient care,” the authors write.
Extra info:
Tinsae Anebo et al, Gastroesophageal Reflux Illness (GERD) and Threat of Incident Acute Myocardial Infarction: A Systematic Evaluate and Meta‐Evaluation of Cohort Research, JGH Open (2025). DOI: 10.1002/jgh3.70295
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Gastroesophageal reflux illness linked to elevated threat for incident acute myocardial infarction (2025, October 23)
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