Optoelectronically energetic bioink composition and printing. (A) Schematic of bioprinting combining μ-solar cells and GelMA after which seeding with CMs. (B) Pictures of the bioprinting course of (i, ii, and iii) of the optoelectronic coronary heart (atria and ventricles) together with a aspect view. Inset reveals the mannequin coronary heart with the printed portion in blue and the rest of the center in grey. (C) Instance of in vivo implantation of a printed optoelectronically energetic tissue and correction of arrhythmic beating. Credit score: Science Advances (2025). DOI: 10.1126/sciadv.adt7210
Researchers from Mass Basic Brigham and collaborating establishments have developed a non-invasive strategy to control cardiac tissue exercise by utilizing gentle to stimulate an progressive ink included into bioprinted tissue. Their aim is to develop a method that can be utilized to restore the center. Their findings in preclinical fashions, printed in Science Advances, present the transformative potential of non-invasive therapeutic strategies to regulate electrically energetic tissues.
“We showed for the first time that with this optoelectronically active ink, we can print scaffolds that allow remote control of engineered heart tissues,” stated co-corresponding creator Y. Shrike Zhang, Ph.D., of the Division of Engineering in Drugs at Brigham and Girls’s Hospital, a founding member of the Mass Basic Brigham well being care system. “This approach paves the way for non-invasive light stimulation, tissue regeneration, and host integration capabilities in cardiac therapy and beyond.”
Three-dimensional bioprinted tissues composed of cells and different body-compatible supplies are a robust rising instrument to restore broken coronary heart tissue. However most bioprinted tissues can’t generate the mandatory electrical exercise for mobile perform. They have to as a substitute depend on invasive wire and electrode placement to regulate coronary heart exercise, which may injury physique tissues.
Zhang and his colleagues addressed this limitation by infusing the bioprinted tissue with the “optoelectronically active” ink that may be remotely stimulated by gentle to generate electrical exercise in these tissues. The authors additionally confirmed that these new, dynamic engineered tissues can synchronize with and speed up the center price when stimulated by gentle in preclinical fashions.
“Now that we have established the proof-of-concept for this technology, we are shifting our efforts towards understanding how it might promote long-term tissue regeneration and integrating it seamlessly within the heart’s biology,” stated Zhang.
Extra info:
Faheem Ershad et al, Bioprinted optoelectronically energetic cardiac tissues, Science Advances (2025). DOI: 10.1126/sciadv.adt7210
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Mass Basic Brigham
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Gentle-activated ink developed to remotely management cardiac tissue to restore the center (2025, January 24)
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