Gestational publicity to nonsteroidal anti-inflammatory medicine (NSAIDs) is related to an elevated threat for childhood power kidney illness (CHD), though the affiliation isn’t seen in sibling comparisons, in response to a examine printed in JAMA Pediatrics.
You-Lin Tain, M.D., Ph.D., from Kaohsiung Chang Gung Memorial Hospital and the Chang Gung College School of Medication in Taiwan, and colleagues examined the affiliation between gestational publicity to NSAIDs and the chance for CKD in childhood in a cohort examine involving 1,025,255 youngsters born alive in Taiwan from Jan. 1, 2007, to Dec. 31, 2017, with follow-up till Dec. 31, 2021.
The examine included 163,516 singleton-born youngsters whose moms used not less than one meting out of an NSAID throughout being pregnant. The researchers noticed a big affiliation between gestational NSAID publicity and the next threat for childhood CKD (weighted hazard ratio [wHR], 1.10). In sibling comparisons, there was no affiliation seen between NSAID use and fetal nephrotoxicity. In singleton-born youngsters, elevated dangers had been seen for publicity throughout the second and third trimesters (wHRs, 1.19 and 1.12, respectively).
Particular NSAID exposures related to elevated CKD threat included indomethacin and ketorolac within the first trimester (wHRs, 1.69 and 1.28, respectively); diclofenac and mefenamic acid within the second trimester (wHRs, 1.27 and 1.29, respectively); and ibuprofen within the third trimester (wHR, 1.34).
“Future research should investigate the specific roles of genetic and environmental factors in kidney development across different stages of pregnancy,” the authors write.
Extra data:
You-Lin Tain et al, Gestational Publicity to Nonsteroidal Anti-Inflammatory Medication and Threat of Power Kidney Illness in Childhood, JAMA Pediatrics (2024). DOI: 10.1001/jamapediatrics.2024.4409
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