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Due to vaccinations in opposition to SARS-CoV-2 within the interval 2020–2024, 2.533 million deaths have been prevented on the world degree; one loss of life was prevented for each 5,400 doses of vaccine administered.
Some 82% of the lives saved by vaccines concerned individuals vaccinated earlier than encountering the virus, 57% throughout the omicron interval, and 90% concerned individuals aged 60 years and older. In all, vaccines have saved 14.8 million years of life (one 12 months of life saved for 900 doses of vaccine administered).
These are a few of the information launched in an unprecedented examine revealed within the journal Jama Well being Discussion board and coordinated by Prof. Stefania Boccia, Professor of Basic and Utilized Hygiene at Università Cattolica, with contributions from Dr. Angelo Maria Pezzullo, researcher typically and utilized hygiene, and Dr. Antonio Cristiano, a medical resident in hygiene and preventive drugs.
The 2 researchers spent a interval at Stanford College, collaborating immediately with the group of Professor John P.A. Ioannidis, director of the Meta-Analysis Innovation Heart (METRICS), within the context of the mission “European network staff eXchange for integrAting precision health in the health Care sysTems- ExACT.”
Professor Boccia and Dr. Pezzullo clarify, “Before ours, several studies tried to estimate lives saved by vaccines with different models and in different periods or parts of the world, but this one is the most comprehensive because it is based on worldwide data, it also covers the omicron period, it also calculates the number of years of life that was saved, and it is based on fewer assumptions about the pandemic trend.”
The consultants studied worldwide inhabitants information, making use of a collection of statistical strategies to determine who among the many individuals who grew to become sick with COVID did both earlier than or after getting vaccinated, earlier than or after the omicron interval, and what number of of them died (and at what age).
“We compared this data with the estimated data modeled in the absence of COVID vaccination and were then able to calculate the numbers of people who were saved by COVID vaccines and the years of life gained as a result of them,” Dr. Pezzullo explains.
It additionally turned out that many of the saved years of life (76%) concerned individuals over 60 years of age, however residents in long-term care services contributed solely 2% of the whole quantity. Kids and adolescents (0.01% of lives saved and 0.1% of life years saved) and younger adults aged 20–29 (0.07% of lives saved and 0.3% of life years saved) contributed little or no to the whole profit.
Professor Boccia concludes, “These estimates are considerably extra conservative than earlier calculations that targeted primarily on the primary 12 months of vaccination, however clearly display an essential total profit from COVID-19 vaccination over the interval 2020–2024.
“Most of the benefits, in terms of lives and life-years saved, have been secured for a portion of the global population who are typically more fragile, the elderly.”
Extra info:
International Estimates of Lives and Life-Years Saved by COVID-19 Vaccination Throughout 2020-2024, JAMA Well being Discussion board (2025).
Supplied by
Catholic College of the Sacred Coronary heart
Quotation:
Globally, over 2.5 million COVID deaths prevented worldwide due to vaccines, information point out (2025, July 25)
retrieved 26 July 2025
from https://medicalxpress.com/information/2025-07-globally-million-covid-deaths-worldwide.html
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