For adults with obese or weight problems with out diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are efficacious for weight reduction, based on a assessment revealed on-line Jan. 7 within the Annals of Inner Drugs.
Areesha Moiz, from McGill College in Montreal, and colleagues examined the efficacy and security of GLP-1 RAs and co-agonists for weight problems therapy amongst adults with out diabetes in a scientific assessment of placebo-controlled randomized managed trials (RCTs) in in any other case wholesome adults with obese or weight problems. Twenty-six RCTs, with 15,491 individuals and 12 brokers (three commercially accessible and 9 premarket), have been included.
The researchers discovered that tirzepatide (15 mg as soon as weekly), semaglutide (2.4 mg as soon as weekly), and liraglutide (3.0 mg as soon as every day) resulted in weight lack of as much as 17.8, 13.9, and 5.8% after 72, 68, and 26 weeks of remedy, respectively, in contrast with placebo. Retatrutide (12 mg as soon as weekly) resulted in weight lack of as much as 22.1% after 48 weeks; different novel single and mixture GLP-1 brokers have been additionally efficacious. Antagonistic occasions have been frequent (80 to 97% versus 63 to 100% for GLP-1 RA versus placebo); most have been gastrointestinal-related, together with nausea, vomiting, diarrhea, and constipation.
“Our results support the use of GLP-1 RAs and co-agonists for the treatment of overweight or obesity among patients without diabetes,” the authors write.
Extra info:
Areesha Moiz et al, Efficacy and Security of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Amongst Adults With out Diabetes, Annals of Inner Drugs (2025). DOI: 10.7326/ANNALS-24-01590
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GLP-1 RAs efficacious for weight reduction in obese, weight problems with out diabetes (2025, January 7)
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