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New analysis reveals that extra weight is linked to an particularly excessive threat of growing breast most cancers in postmenopausal ladies with heart problems. The findings are printed in Most cancers.
Though increased physique mass index (BMI) is a recognized threat issue for breast most cancers in postmenopausal ladies, it is unclear whether or not this threat differs amongst ladies with and with out heart problems or sort 2 diabetes. To analyze, a crew led by Heinz Freisling, Ph.D., of the Worldwide Company for Analysis on Most cancers (the specialised most cancers company of the World Well being Group) analyzed information from the European Potential Investigation into Most cancers and Diet (EPIC) and UK Biobank on 168,547 postmenopausal ladies who didn’t have sort 2 diabetes or heart problems after they agreed to take part.
After a median follow-up of 10.7 years in EPIC and 10.9 years within the UK Biobank, 6,793 postmenopausal ladies developed breast most cancers. In a pooled evaluation of each research, every 5 kg/m2 improve in BMI was related to a 31% increased threat of breast most cancers in ladies who developed heart problems throughout follow-up and a 13% increased threat in ladies with out heart problems. The event of sort 2 diabetes didn’t appear to have an effect on breast most cancers threat: Girls with or with out sort 2 diabetes had a equally elevated breast most cancers threat associated to increased BMI.
The mixture of obese (BMI ≥ 25 kg/m2) and heart problems was estimated to result in 153 extra instances of breast most cancers per 100,000 folks per 12 months than anticipated.
“The findings of this study could be used to inform risk-stratified breast cancer screening programs,” stated Dr. Freisling. “This study should also inspire future research to include women with a history of cardiovascular diseases in weight-loss trials for breast cancer prevention.”
Extra info:
Physique mass index and breast most cancers threat amongst postmenopausal ladies with and with out cardiometabolic ailments: findings from two potential cohort research in Europe, Most cancers (2025). DOI: 10.1002/cncr.35911
Quotation:
How physique mass index impacts breast most cancers threat in postmenopausal ladies with and with out heart problems (2025, July 7)
retrieved 7 July 2025
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